N0期胃癌患者的临床病理特征及预后分析

目的:探讨N0期胃癌患者的临床病理特征及影响预后的危险因素。方法:回顾性分析2003年3月至2012年3月我科收治的296例N0期胃癌患者的临床病理资料。分析其临床病理特征以及通过单因素和多因素分析影响其预后的危险因素。结果:本研究中男性248例，女性48例。中位年龄58岁（28~82岁）。中位肿瘤大小4 cm（0.3~15 cm）。168例患者为TNM I期，126例患者为TNM II期，仅2例患者为TNM III期。患者的中位随访时间为62.3个月（1~73.4个月）。1、3、5年总体生存率分别为97.6%、89.2%和83.7%。单因素分析显示切除方式、CEA、CA125、脉管侵犯、T分期和TNM分期为影响N0期胃癌患者预后的危险因素（P<0.05）。然而，仅CEA、CA125、脉管侵犯和T分期为影响预后的独立危险因素（P＜0.05）。结论:N0期胃癌患者总体预后较好。CEA、CA125、脉管侵犯和T分期为影响N0期胃癌患者预后的独立危险因素。

Clinicopathological features and prognosis of stage N0 gastric cancer

Objective:To investigate the clinicopathological features and prognosis of stage N0 gastric cancer.Methods:From March 2003 to March 2012，the clinicopathological features and risk factors of 296 stage N0 gastric cancer patients were retrospectively analyzed.Results:There were 248 males and 48 females.The median age was 58 years(28~82 years).The median tumor size was 4 cm(0.3~15 cm).168 cases were stage I tumor，126 cases were stage II tumor and 2 cases were stage III tumor.The median follow up duration was 62.3 months(1~73.4 months).The 1，3，and 5-year overall survival rate was 97.6%，89.2% and 83.7%，respectively.The univariate analysis showed that type of resection，CEA，CA125，lymphatic-vascular invasion，tumor depth and TNM stage were risk factors for the prognosis of stage N0 gastric cancer(all P<0.05).However，only CEA，CA125，lymphatic-vascular invasion and tumor depth were independent risk factors for the prognosis of patients (all P＜0.05).Conclusion:The prognosis of stage N0 gastric cancer patients was promising.CEA，CA125，lymphatic-vascular invasion and tumor depth were independent risk factors for the prognosis of stage N0 gastric cancer patients.