生脉地黄汤治疗糖尿病肾病的疗效及对血清胱抑素C水平的影响

 目的 观察自拟生脉地黄汤治疗早中期糖尿病肾病(diabetic nephropathy,DN)患者的临床疗效及对患者血清胱抑素C(Cys-C)等指标的影响。方法 选取门诊2016-01至2018-01诊治的102例早中期DN患者作为研究对象,随机分为对照组与观察组,每组51例。对照组给予常规治疗,观察组在常规治疗基础上给予自拟生脉地黄汤治疗;治疗3个月为1个疗程,评估两组临床疗效,观察两组患者治疗前、后肾功能指标、血糖指标、血清标志物表达水平的变化情况。结果 观察组临床总有效率为92.16%,对照组临床总有效率为72.55%;治疗后,观察组整体疗效水平与总有效率均高于对照组,差异有统计学意义(P<0.05)。两组血糖指标(FBG、2 hPG、HbA₁c)、肾功能指标(SCr、BUN、U-β₂MG、24 h尿蛋白总量)、血清标志物(Cys-C、RBP、Hcy)与治疗前对比,差异均有统计学意义(P<0.05);治疗后,观察组上述各项指标均优于对照组,差异有统计学意义(P<0.05)。结论 生脉地黄汤治疗糖尿病肾病疗效可靠,可有效改善患者肾功能、降低血清Cys-C等标志物的表达水平。

Clinical effect of Shengmai Dihuang decoction against diabetic nephropathy and its effect on serum cystatin C levels

Objective To observe the clinical efficacy of Shengmai Dihuang decoction in the treatment of early and middle stage diabetic nephropathy and its effect on serum cystatin C (Cys-C) and other indicators.Methods One hundred and two patients with early-stage diabetic nephropathy (DN) admitted to our hospital between January 2016 and January 2018 were selected as the subjects,who were divided into the control group and the observation group. The control group was given routine treatment while the observation group was additionally given self-designed Shengmai Dihuang decoction. One course of treatment lasted 3 months.The clinical efficacy of the two groups was evaluated after one course of treatment, and changes in renal function indicators, blood glucose indicators and serum marker expression levels of the two groups of patients were observed after treatment.Results The total effective rate of the observation group was 92.16%, compared with 72.55% in the control group, so the difference was statistically significant.The difference in such blood glucose indexes as FBG,2hPG and HbA₁c, in renal function indexes including SCr,BUN, U-β₂MG, and total urine protein at 24 h and in such serum markers as Cys-C,RBP,and Hcy was statistically significant between the two groups (P<0.05)after treatment. All the above indicators in the observation group were better than those in the control group(P<0.05).Conclusions Shengmai Dihuang decoction is effective in the treatment of diabetic nephropathy and can effectively improve the renal function of patients and reduce the expression levels of serum Cys-C markers.