NEI VFQ-25中文版在老年性黄斑变性患者中应用的性能评价

目的 对视功能相关生命质量量表（National Eye Institute 25-Item Visual Function Questionnaire，NEI VFQ-25）中文版在老年性黄斑变性（age-related macular degeneration, AMD）患者中的应用进行信度和效度评价。设计 诊断试验。研究对象 AMD 患者107例及正常对照69例。方法 分别利用健康危险因素调查问卷和中文版NEI VFQ-25对上述研究对象进行一般情况和视功能相关生存质量调查。根据受调查者的得分情况，采用内部一致性信度、分半信度评价量表信度，内容效度、结构效度和区分效度评价量表效度。主要指标 信度和效度。结果 结果显示量表的信度良好，总体Cronbach α信度系数、分半信度系数分别为0.83和0.77；探索性因子分析12个维度共得到3个公因子，累计方差贡献率为65.35%，表明量表结构效度良好；病例组、对照组在各维度得分不同（P<0.05），说明量表区分效度良好。 结论 中文版NEI VFQ-25量表在评价AMD患者视功能相关生存质量方面具有良好的信度和效度，适用于综合评价AMD所导致的视力损伤对生存质量的影响。

Performance evaluation of Chinese version vision-related quality of life scales of NEI-VFQ-25 in age-related macular degeneration

Objective To evaluate the reliability and validity of the Chinese version of the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) in aged-related macular degeneration (AMD) patients. Design Diagnostic test. Participants A total of 107 AMD patients and 69 controls were included. Methods The health risk factors questionnaire and the Chinese version of NEI VFQ-25 were used to examine the baseline characteristics and vision-related quality of life, respectively. According to the scores of subjects, the internal consistency reliability, split-half reliability, construct validity and discriminant validity were carried out to evaluate the validity of the questionnaire. Main Outcome Measures Reliability and validity. Results The reliability of the questionnaire was good, and the Cronbach’ alpha coefficient and Spearman-Brown split-half coefficient were 0.827 and 0.772, respectively. Three common factors were extracted from 12 dimensionality by principal component analysis and the accumulated variance rate of contribution was 65.35%, suggesting a good construct validity. The discriminant validity test results between the AMD and control group were statistically significant in all the subscales of NEI VFQ-25 (P<0.05), indicating a good discriminant validity of the questionnaire. Conclusion The Chinese version questionnaire of NEI VFQ-25 has good reliability and validity in evaluating the visual function damage for patients with AMD, which can be implemented as a good scale and evaluation tool for the life quality of those persons with AMD.