大网膜原发性骨外软骨瘤1例并文献复习

目的:探讨大网膜原发性骨外软骨瘤的临床病理特征、鉴别诊断、治疗及预后。方法:分析一例33岁女性患者的临床资料，对病理标本进行常规HE染色和免疫组化染色，对染色结果进行分析判读，并检索国内外文献进行复习。结果:超声及CT均提示患者腹腔有包块；大体标本检查肿瘤组织部分呈分叶状，界清、质硬、灰白，周边见部分网膜组织；组织病理检查肿瘤由成熟透明软骨构成，呈小叶状排列，细胞无异型性；免疫组化检测肿瘤组织S-100阳性，Ki67阳性指数<1%；随访患者3年无复发或转移，各项结果共同支持大网膜原发性骨外软骨瘤的诊断，临床治疗方法首选完整切除。结论:大网膜原发性软骨瘤极其罕见，其发病机制尚不明确，治疗以手术完整切除为主。

Primary extraskeletal chondroma of the greater omentum:Case report and review of literature

Objective:To explore the clinicopathological characteristics，differential diagnosis，treatment and prognosis in primary extraskeletal chondroma of the greater omentum.Methods:The clinical data of a 33-year-old woman was analyzed.Hematoxylin-eosin staining and immunohistochemistry were performed and the results were analyzed.In addition，we reviewed the domestic and international literature.Results:Ultrasound and computed tomography showed a mass in the abdomen of patient.Grossly，the tumor was lobulated，well-circumscribed，hard and gray.Around the tumor，there was a part of greater omentum.Histopathologically，the tumor was composed of mature hyaline cartilage，and arranged like lobular.The cells were not atypical.Immunohistochemically，S-100 was positive and Ki67 index was below 1%.The patient was doing very well with no complaints or metastasis after 2 years.All of the features were in accordance with the primary extraskeletal chondroma of the greater omentum.Resection was considered as the recommended therapy.Conclusion:The primary extraskeletal chondroma of the greater omentum is very rare，and the etiology is unknown.The therapy should be chosed is surgical resection.