骨肉瘤相关的lncRNA研究进展

骨肉瘤是临床常见的原发性恶性骨肿瘤，由于恶性程度高，转移发生早，骨肉瘤的治疗效果至今仍不理想，研究骨肉瘤恶性生物学特征的分子机制并探索高效的治疗方式，已成为国内外对骨肉瘤研究的热点。lncRNA（long non-coding RNA）是一类长链非编码RNA，参与多种细胞功能的调控，对肿瘤的发生发展起重要作用。近年来，lncRNA在骨肉瘤中的研究报道越来越多，lncRNA通过与蛋白质、mRNA、miRNA等相互作用，影响骨肉瘤细胞的增殖、侵袭和迁移。本文结合近年报道，对lncRNA在骨肉瘤分子机制中的研究做一综述。 

Research progress on lncRNA related to osteosarcoma

Osteosarcoma is a clinically common primary malignant bone tumor. Its treatment is still not ideal because of the high degree of malignancy and early metastasis. Understanding the molecular mechanism and the biological characteristics of malignant osteosarcoma, and exploring the effective treatment have become the focus of osteosarcoma research at home and abroad. A long noncoding RNA, lncRNA, is involved in the regulation of a variety of cellular functions and plays an important role in the development of osteosarcoma. Recently, lncRNA has been increasingly reported in osteosarcoma research. It has been found to affect the proliferation, invasion, and migration of osteosarcoma cells by interacting with proteins, mRNAs, and miRNAs. This article reviews the research on lncRNA based on recent reports regarding its role in the molecular mechanism of osteosarcoma.