癌痛管理相关进展及全球差异性

在全球范围内，癌痛仍然是一个重要的临床问题。癌症引发疼痛的机制复杂、多种多样。伴随癌痛的生物学进展，越来越多的人认为癌痛是肿瘤细胞与宿主免疫、周围神经系统与中枢神经系统之间的交叉效应所致的结果。癌痛管理是控制疼痛、提高病人生活质量的不可或缺的治疗手段，癌痛治疗的选择也应根据不同个体量身定制。阿片类药物仍然是治疗癌痛最有效的药物，而神经调节作为治疗神经性癌痛的新兴技术也发展迅速。当前，全球范围内镇痛药物的可用性存在差异，中低收入国家明显低于高收入国家。在未来的几十年，全球癌症负担将逐年加重，因此提高全社会的癌痛管理意识迫在眉睫。

The advance and global disparities on cancer pain management

Undoubtedly，cancer pain is an important clinical problem in worldwide.The cause of cancer pain is multifaceted and complex，because of the different pain mechanisms with the different patients.With the development of cancer pain，more and more people believe that cancer pain is the result of cross effect between tumor cells and host immunity，peripheral nervous system and central nervous system.Cancer pain management plays an indispensable role in cancer patients.Opioids is still the most effective drugs for treatment of cancer pain，and neuromodulation may play an important role in the treatment of neuropathic pain.Cancer pain management is an indispensable way to control pain and improve the life quality of patients，and the choice of pain treatment should also be customized according to different individuals.There are disparities in availability of analgesic drugs worldwide，with LMIC significantly lower than high-income countries.In the coming decades，the global cancer burden will increasing year by year，therefore it is important to improve the awareness of cacer pain management.