| OPRM1（A118G）基因多态性对阿片类药物镇痛效应影响的研究进展 |
| |
| 引用本文： | 陆彦霓,汤晓青,沈丽达. OPRM1（A118G）基因多态性对阿片类药物镇痛效应影响的研究进展[J]. 现代肿瘤医学, 2018, 0(9): 1477-1480. DOI: 10.3969/j.issn.1672-4992.2018.09.043 |
| |
| 作者姓名： | 陆彦霓 汤晓青 沈丽达 |
| |
| 作者单位： | 云南省肿瘤医院（昆明医科大学第三附属医院）内一科，云南 昆明 650118 |
| |
| 基金项目： | National Natural Science Foundation of China（No.81472597）；国家自然科学基金资助项目（编号:81472597） |
| |
| 摘 要： | 疼痛是中晚期癌症患者的常见症状，阿片类药物是治疗中重度癌痛的主要药物之一，主要通过μ-阿片受体基因(OPRM1)编码的μ-阿片受体发挥镇痛作用。临床发现，阿片类药物镇痛效果、不良反应及阿片耐受的发生存在一定个体差异。许多研究表明，这种个体差异与OPRM1基因A118G位点密切相关，本文就OPRM1（A118G）基因多态性与阿片类药物镇痛效应的相关研究作一综述。
|
| 关 键 词： | OPRM1（A118G）基因 阿片类药物 癌痛 镇痛 |
Progress in OPRM1 (A118G) gene polymorphism with opioid analgesic effect |
| |
| Lu Yanni,Tang Xiaoqing,Shen Lida. Progress in OPRM1 (A118G) gene polymorphism with opioid analgesic effect[J]. Journal of Modern Oncology, 2018, 0(9): 1477-1480. DOI: 10.3969/j.issn.1672-4992.2018.09.043 |
| |
| Authors: | Lu Yanni Tang Xiaoqing Shen Lida |
| |
| Affiliation: | The First Department of Medical Oncology，Yunnan Cancer Hospital(The Third Affiliated Hospital of Kunming Medical University)，Yunnan Kunming 650118，China. |
| |
| Abstract: | Pain is a common symptom in advanced cancers.Opioids are one of the main drugs for the treatment of moderate and severe cancer pain，which analgesic action is mainly mediated by mu opioid receptors that are encoded by the mu opioid receptor gene (OPRM1).The clinical studies showed that there were some individual differences in opioid analgesic efficacy，adverse reaction and opioid tolerance.Several studies have showen that this individual difference close association with the A118G site of OPRM1 gene.This article reviews the related studies of OPRM1 (A118G) gene polymorphism and opioid analgesic effect. |
| |
| Keywords: | OPRM1 (A118G) gene opioid cancer pain analgesia |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
