| PI3K/Akt信号通路与肿瘤血管新生的研究进展 |
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| 引用本文： | 耿军辉1,张丽军2,' target='_blank'>3,王亚丽3,付建珠3,齐雪军2,' target='_blank'>3,成志勇3,张金金3. PI3K/Akt信号通路与肿瘤血管新生的研究进展[J]. 现代肿瘤医学, 2018, 0(9): 1462-1466. DOI: 10.3969/j.issn.1672-4992.2018.09.039 |
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| 作者姓名： | 耿军辉1 张丽军2 ' target='_blank'>3 王亚丽3 付建珠3 齐雪军2 ' target='_blank'>3 成志勇3 张金金3 |
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| 作者单位： | 1.定州市人民医院，河北 定州 073000；2.承德医学院，河北 承德 067000；3.保定市第一医院，河北 保定 071000 |
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| 基金项目： | 河北省重点科技计划项目（编号:162777120D） |
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| 摘 要： | PI3K/Akt信号通路在多种细胞中活化，参与细胞的增殖、分化、凋亡、血管新生等病理、生理过程。血管的生成需要PI3K/Akt信号通路的激活，PI3K/Akt活化后可以广泛诱导鸡胚尿囊膜血管的生成。PI3K/Akt信号通路与其下游信号分子mTOR及多种促血管新生因子，如VEGF、HIF等相互作用，从而促进肿瘤血管新生。PI3K/Akt信号通路抑制剂能够抑制其血管新生作用，因此靶向PI3K/Akt信号通路为恶性肿瘤靶向治疗提供了新方法。
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| 关 键 词： | PI3K Akt mTOR VEGF 血管新生 |
The progress of PI3K/Akt signaling pathway and tumor angiogenesis |
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| Geng Junhui1,Zhang Lijun2,' target='_blank'>3,Wang Yali3,Fu Jianzhu3,Qi Xuejun2,' target='_blank'>3,Cheng Zhiyong3,Zhang Jinjin3. The progress of PI3K/Akt signaling pathway and tumor angiogenesis[J]. Journal of Modern Oncology, 2018, 0(9): 1462-1466. DOI: 10.3969/j.issn.1672-4992.2018.09.039 |
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| Authors: | Geng Junhui1 Zhang Lijun2 ' target='_blank'>3 Wang Yali3 Fu Jianzhu3 Qi Xuejun2 ' target='_blank'>3 Cheng Zhiyong3 Zhang Jinjin3 |
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| Affiliation: | 1.People's Hospital of Dingzhou，Hebei Dingzhou 073000，China；2.Chengde Medical University，Hebei Chengde 067000，China；3.The No.1 Hospital of Baoding，Hebei Baoding 071000，China. |
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| Abstract: | PI3K/Akt signaling pathway is activated in variety of cells.It is involved in the pathological and physiological processes of cell proliferation，differentiation，apoptosis and angiogenesis.Angiogenesis is required for activation of the PI3K/Akt signaling pathway，and activation of PI3K/Akt induces extensive angiogenesis in chick embryo chorioallantoic membranes.The PI3K/Akt signaling pathway interacts with its downstream signaling molecule mTOR and a variety of angiogenic factors such as VEGF and HIF，then enhancing tumor angiogenesis.Inhibitors of PI3K/Akt signaling pathway can inhibit their angiogenesis，so targeting PI3K/Akt signaling pathway provides a new approach for targeted therapy of malignant tumors. |
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| Keywords: | PI3K Akt mTOR VEGF angiogenesis |
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