Hepcidin在恶性血液病贫血患者中的表达及临床意义

目的:探讨铁调素(hepcidin)在恶性血液病贫血患者中的表达，并对hepcidin与白细胞介素6 (interleukin-6，IL-6)、血红蛋白(hemoglobin，Hb)、血清铁和铁蛋白表达水平进行相关性分析。方法:收集80例恶性血液病贫血患者外周血，分别检测hepcidin、IL-6、Hb、血清铁和铁蛋白的表达水平，并以30例健康人群作为对照；使用SPSS 21.0软件对实验结果进行统计学分析。结果:恶性血液病贫血患者血清中hepcidin、IL-6、Hb、血清铁和铁蛋白的表达量分别为(61.93±19.98) μg/L、(5.56±1.17) ng/L、(96.68±12.35) g/L、(9.85±1.09) μmol/L和329.42(299.70~459.06) μg/L；健康对照组相对应的表达量分别为(21.35±7.38) μg/L、(2.52±1.28) ng/L、(140.07±7.71) g/L、(19.95±4.25) μmol/L和95.72(76.56~131.42) μg/L，两组差异均具有统计学意义(P<0.01)。恶性血液病男性贫血患者中hepcidin、IL-6和Hb的表达量均高于女性患者(P<0.05)；中度贫血患者hepcidin、IL-6和铁蛋白的表达量均高于轻度贫血患者，Hb和血清铁表达量低于轻度贫血患者(P<0.01)。线性回归分析结果显示hepcidin与Hb、血清铁含量呈负相关，与IL-6、铁蛋白含量呈正相关(P<0.05)。结论:Hepcidin在恶性血液病贫血患者中高表达，并与贫血程度相关，提示hepcidin在恶性血液病贫血发生中具有重要作用。

Expression and clinical significance of hepcidin in patients with anemia of hematologic malignancies

Objective:To investigate the expression of hepcidin and the correlation analysis of hepcidin with interleukin-6 (IL-6)，hemoglobin (Hb)，serum iron and ferritin in patients with anemia of hematologic malignancies.Methods:Collect the peripheral blood of 80 cases with anemia of hematologic malignancies and detect the expression level of hepcidin，IL-6，Hb，serum iron and ferritin，while 30 healthy people as control group.Statistical analysis was performed using SPSS software，version 21.0.Results:The expressions of hepcidin，IL-6，Hb，serum iron and ferritin in patients with anemia of hematologic malignancies were (61.93±19.98) μg/L，(5.56±1.17) ng/L，(96.68±12.35) g/L，(9.85±1.09) μmol/L and 329.42 (299.70~459.06) μg/L，respectively，while the corresponding expressions in the healthy people were (21.35±7.38) μg/L，(2.52±1.28) ng/L，(140.07±7.71) g/L，(19.95±4.25) μmol/L and 95.72 (76.56~131.42) μg/L，and the differences between the two groups were statistically significant (P<0.01).The expressions of hepcidin，IL-6 and Hb were up-regulated in male patients compared with female patients (P<0.05).Compared with patients with mild anemia，the expressions of hepcidin，IL-6 and ferritin were up-regulated and the expressions of Hb and serum iron were down-regulated in patients with moderate anemia (P<0.05).The results of linear regression analysis showed that hepcidin was negatively correlated with Hb and serum iron，and positively correlated with IL-6 and ferritin (P<0.05).Conclusion:Hepcidin was up-regulated in patients with anemia of hematologic malignancies，and associated with anemia level，which indicated that hepcidin was important in anemia of hematologic malignancies.