TDP-43与神经退行性疾病及脑损伤的相关性研究进展

TAR DNA/RNA结合蛋白43 (TARDNA/RNA-binding domain protein 43, TDP-43) 是一种高度保守、广泛表达的核蛋白.肌萎缩侧索硬化症 (amyotrophic lateral sclerosis, ALS) 、额颞叶变性 (frontotemporal lobar degeneration, FTLD) 、阿尔茨海默病 (alzheimer disease, AD) 等神经退行性疾病的病理学标记蛋白被公认是TDP-43.就TDP-43的结构、功能及其与神经退行性疾病之间的关系作一综述.同时在对TDP-43生物学特性认识的基础上, 探讨TDP-43在急、慢性颅脑损伤中的特殊表达与作用, 从而探索TDP-43在法医病理学中确定死亡原因、判定致伤致残情况的可行性.

Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury

TAR DNA/RNA-binding domain protein 43 (TDP-43) is a highly conserved and widely expressed nuclear protein. TDP-43 is recognized as a pathological marker protein of amyotrophic lateral sclerosis (ALS) , frontotemporal lobar degeneration (FTLD) and alzheimer disease (AD) .This article discusses the structure and the function of TDP-43 and the relationship of its expression in neurodegenerative disease.Meanwhile, this article emphatically probes into the specific expression andfunction of TDP-43 in acute and chronic brain injury based on the knowledge of its biological characteristics, aiming to explore the feasibility for determining the cause of death and the injury and disability situations by TDP-43 in forensic pathology.