陕西地区丙肝患者分型与疗效分析

目的 对陕西省内三家大型医院就诊丙肝患者做丙肝基因分型, 并对分型结果做实验指标与疗效分析, 以期发现其中的变化规律.方法 对就诊437例丙肝阳性患者中的253例丙肝分型阳性患者做实验指标和病情分析.结果 各型丙肝肝功能实验其中4项指标、胆汁酸受体I含量和丙肝基因含量差异有统计学意义 (P<0.05) ;丙肝不同亚型聚乙二醇干扰素加利巴韦林治疗后疗效, 差异无统计学意义 (P>0.05) , 但治愈率和好转率各型差异有统计学意义 (P<0.05) .结论 陕西省内丙肝患者以Ib型和Ⅱa型为主, 肝功能4项指标、丙肝基因含量和胆汁酸受体I含量在病情严重程度判断与治疗上有重要意义.3 b、3 a和6 a型治愈率和好转率较高, 1 b、1a和2 a型治愈率和好转率较低.口服药物对丙肝治疗效果提高.

An Analysis of the Classification and Therapeutic Effects of Hepatitis C Patients in Shaanxi

Objective To study the genotypes of hepatitis C patients in three large hospitals in Shanxi Province, and to analyze the results of the classification. Methods Genotypes and related disease markers of253 cases of hepatitis C positive patients in a total of 437 cases were analyzed.Results There was a significant difference in the I content of each type of bile acid receptor and HCV gene content among all HCV Classification patients (P<0.05) while there was no significant difference in the therapeutic effects of pegylated interferon and Galebavirin in different subtypes of HCV (P>0.05) . Conclusions Hepatitis C patients in Shanxi province are mainly type Ib and type II A, and there are significant differences in each type of gene content (P<0.05) . The content of I of bile acid receptor is of great significance in the judgement and treatment of the disease.Type 3 b, type 3 a and type 6 a have higher cure rates and better recovery rates, while type1 b, type 1 a and type 2 a have lower cure rates and recovery rates.The use of oral drugs makes hepatitis C treatment better.