| 胰高血糖素样肽-1改善非酒精性脂肪性肝病作用机制研究进展* |
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| 引用本文： | 信丰智 综述,曹海霞,范建高 审校. 胰高血糖素样肽-1改善非酒精性脂肪性肝病作用机制研究进展*[J]. 实用肝脏病杂志, 2018, 21(2): 313-316. DOI: 10.3969/j.issn.1672-5069.2018.02.047 |
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| 作者姓名： | 信丰智 综述 曹海霞 范建高 审校 |
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| 作者单位： | 200092 上海市 上海交通大学医学院附属新华医院消化内科 |
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| 基金项目： | *国家自然科学基金资助项目（编号：81270491） |
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| 摘 要： | 近期研究表明,胰高血糖素样肽-1受体激动剂可从改善肝细胞脂质代谢、抑制炎症反应、调节细胞自噬等多个环节减轻非酒精性脂肪性肝病（NAFLD）患者肝脏脂质沉积,改善组织学损伤,有望成为治疗NAFLD药物的新选择。
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| 关 键 词： | 非酒精性脂肪性肝病 胰高血糖素样肽-1 作用机制 |
| 收稿时间： | 2017-01-10 |
Glucagon-like peptide-1 in melioration of non-alcoholic fatty liver disease |
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| Xin Fengzhi,Cao Haixia,Fan Jiangao. Glucagon-like peptide-1 in melioration of non-alcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2018, 21(2): 313-316. DOI: 10.3969/j.issn.1672-5069.2018.02.047 |
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| Authors: | Xin Fengzhi Cao Haixia Fan Jiangao |
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| Affiliation: | Department of Gastroenterology,Xinhua Hospital,JiaoTong University School of Medicine,Shanghai 200092,China |
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| Abstract: | Glucagon-like peptide-1 receptor agonists could meliorate hepatic lipid deposition and histological damage by regulating lipid metabolism,inflammation and autophagy in pathogenesis of non-alcoholic fatty liver disease （NAFLD）,which may serve as a new option for treatment of patients with NAFLD. |
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| Keywords: | Non-alcoholic fatty liver disease Glucagon-like peptide 1 Pathogenesis |
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