新疆地区不同民族原发性肝癌患者的生存及预后分析

目的:探讨新疆地区维吾尔族、汉族、哈萨克族等民族原发性肝癌（primary hepatocellular carcinoma,PHC）患者的临床特征及生存预后。方法:收集整理2004年1月至2016年12月在我院就诊的1 674例PHC患者的临床资料进行回顾性的分析，采用Kaplan-Meier法进行生存分析，采用Log- rank检验对影响患者生存预后的因素进行单因素分析，采用Cox多因素对影响患者生存预后的因素进行多因素分析。通过电话随访了解患者生存情况、生存时间等。结果:1 674例PHC患者中位生存期为23个月，1年累积生存率为57.6%，2年累积生存率为46.0%，3年累积生存率为35.4%,5年累积生存率为24.8%。单因素分析发现，患者族别、城乡地区、是否感染乙肝、是否感染丙肝、AFP水平、肿瘤大小、肿瘤分期、治疗方式，与患者生存预后相关；Cox多因素分析发现，患者的族别、城乡地区差异、AFP水平、是否合并门脉癌栓、肿瘤大小、肿瘤分期、治疗方式是影响我院PHC患者预后的主要独立因素，且综合治疗模式优于单一治疗。结论:新疆地区维吾尔族、汉族、哈萨克族PHC患者的临床特征不同，具有一定地域性。患者族别、分布地区差异、AFP水平、肿瘤大小、肿瘤分期、治疗方式是影响我院PHC生存时间的独立预后因素。

Survival and prognosis of patients with primary hepatocellular carcinoma from different ethnic groups in Xinjiang

Objective:To investigate the clinical characteristics and survival of ethnic PHC in Xinjiang Uyghur,Han and Kazak ethnic groups.Methods:The clinical data of 1 674 PHC patients treated in our hospital from January 2004 to December 2016 were retrospectively analyzed.The Kaplan-Meier method was used to calculate the survival rate.Log rank test was used to evaluate the prognosis of patients with PHC univariate analysis of factors,using Cox multifactorial factors affecting the prognosis of patients with multivariate analysis.Follow-up by phone to understand the patient's survival,survival time and so on.Results:The median survival time of 1 674 patients with primary liver cancer was 23 months.The 1-year cumulative survival rate was 57.6%,the 2-year cumulative survival rate was 46.0% and the 3-year cumulative survival rate was 35.4%.The 5-year cumulative survival rate was 24.8%.Univariate analysis found that patients in different ethnic groups,urban and rural areas,whether infected with hepatitis B,hepatitis C infection,cirrhosis AFP levels,tumor size,tumor staging,treatment,were related in prognosis of patients.Cox multivariate analysis found that the patient's ethnicity,urban and rural areas,AFP level,tumor size,tumor staging,treatment were the main independent prognostic factors in patients with hepatocellular carcinoma in our hospital,and the comprehensive treatment model is superior to single treatment.Conclusion:The clinical features of Uyghur,Han and Kazak PHC patients in Xinjiang are different and have some regional characteristics.The patient's ethnicity,distribution area,AFP level,tumor size,tumor staging and treatment method are the independent prognostic factors that affect the survival time of PHC in our hospital.