角膜基质细胞的表型转化及其预防瘢痕形成的研究

正常情况下角膜基质细胞处于静止状态，受损伤时易发生表型及生理功能的改变，转换为成纤维细胞或肌成纤维细胞。不同的损伤因子影响角膜细胞的应答反应，决定角膜组织是完全修复还是形成瘢痕组织。角膜基质细胞合成分泌多种细胞外基质，活化的角膜基质细胞利于角膜损伤修复，角膜肌成纤维细胞可致角膜表面混浊，损伤、细菌或病毒感染等因素导致角膜受损后修复产生瘢痕，富血小板血浆、转化生长因子β等生化因子在表型转换、瘢痕组织的临床治疗和预防等方面起重要作用。（国际眼科纵览， 2018,  42:   194-198）

Phenotypic transformation of corneal stromal cells and prevention of scar formation

Corneal stromal cells(CSCs), normally in a static state, are prone to change in phenotype and physiological functions when damaged. They can transform into fibroblasts or myofibroblasts. Different injury factors affect the response of corneal cells and determine whether corneal tissue is repaired completely or to form scar tissue. CSCs can synthesize and secrete a variety of extracellular matrix. Activated CSCs are beneficial to repair corneal injury. Corneal myofibroblast may cause turbidity of corneal surface. Injury, infection of bacteria or virus and other factors lead to scarring. Platelet rich plasma, TGF-β and other physicochemical factors play an important role in phenotypic transformation of CSCs, clinical treatment and prevention of corneal scar tissue.(Int Rev Ophthalmol, 2018, 42:  194-198)