钙化性腱膜纤维瘤2例临床病理分析

目的:探讨钙化性腱膜纤维瘤(CAF)临床病理特点、免疫组化、病理诊断与鉴别诊断要点。方法:分析2例CAF临床病理特点、免疫组化、治疗与预后并复习相关文献。结果:CFA好发于青少年手掌和足底。肿瘤多< 3 cm，界不清；切面呈灰白色，质硬。镜下可见增生的纤维母细胞、散在分布的钙化小灶及软骨小岛。免疫组化:vimentin（+），SMA（+），CD68（+），CD99（+）。结论:CAF是一种少见的良性软组织肿瘤，其诊断需要结合临床病理形态学特点及免疫组化，且还需与腱鞘巨细胞瘤、软骨母细胞瘤、肿瘤样钙盐沉着症、掌跖纤维瘤病、婴儿型纤维瘤病、婴儿纤维性错构瘤、软组织软骨瘤、单相纤维型滑膜肉瘤鉴别。

Clinicopathological analysis of two cases of calcifying aponeurotic fibroma

Objective:To investigate the clinicopathological features,immunohistochemistry,pathological diagnosis and differential diagnosis of calcified aponeurotic fibroids (CAF).Methods:Analyze 2 cases of CAF clinical pathological features,immunohistochemistry,treatment,prognosis and review related literature.Results:CAF most commonly occurred in the palms and the soles of the feet of the teenagers.Most tumors were less than 3 cm,the edge was ill-defined,the areas of tumors had a solid pale-gray on cut surface.The proliferating fibroblasts,diffused distributed chondrioid cells and calcific debris can be seen through the microscope.Immunohistochemistry:vimentin(+),SMA(+),CD68(+),CD99(+).Conclusion:CAF is a rare benign soft tissue tumor,its diagnosis needs combining with the clinical pathology features and immunohistochemistry,and still need to be distinguished from ganglion cell tumor,chondroblastoma,tumor-like calcium salts,fibroid disease of the hand,infant fibromatosis,fibrous hamartoma of infants,chondroma of soft tissue,single phase fibrous synovial sarcoma.