从疾病本质出发， 结合我国实际， 精准诊治骨髓增生异常综合征

骨髓增生异常综合征 （MDS） 的本质是一种恶性克隆性骨髓髓系肿瘤性疾病。无论是基础研究还是临床研究都应紧紧抓住这个本质， 不要被混杂因素所干扰。通过反映恶性本质的多个指标， 如细胞发育异常、 功能异常、 染色体异常和基因突变等， 综合诊断能提高诊断的准确性。MDS的治疗也需要考虑根除恶性克隆， 改变疾病病程， 促进正常造血， 延长生命和改善生存质量。

Precision diagnosis and therapy of myelodysplastic syndrome based on disease nature and our facility

Abstract: The essence of myelodysplastic syndrome (MDS) is a malignant clonal bone marrow myeloid neoplasm. Both basic researches and clinical studies should firmly grasp this essence of MDS and should not be interferenced by confounding factors. Comprehensive diagnosis can improve the accuracy of MDS diagnosis by multiple indicators that reflect the malignant nature, such as cell dysplasia, function abnormalities, cytogenetic changes and gene mutations. The therapy of MDS should also eradicate the MDS clone, change the disease progression, stimulating normal hematopoiesis, prolong the survival and improve the quality of life.