甲状腺功能与胃肠运动及胃动素水平的关系

目的 探讨甲状腺功能与胃肠运动及胃动素水平的关系, 为临床应用提供依据.方法 选取2013年1月至2016年1月间四川省人民医院收治的60例甲状腺功能异常患者, 其中30例甲状腺功能亢进患者作为甲亢组、30例甲状腺功能减退患者作为甲减组, 30例健康体检者作为对照组;采用放射免疫法检测血清中胃动素水平, 同位素单光子辐射计算机断层显像技术检测患者胃液体半排时间、食管通过时间.结果 甲减组受试者食管通过时间明显高于甲亢组及对照组, 差异有统计学意义 (P<0.05) , 甲减组显著高于对照组 (P<0.04) ;甲亢组患者血清中胃动素水平显著高于对照组 (P<0.05) , 甲减组患者血清中胃动素水平显著低于对照组 (P<0.05) ;甲亢与胃动素水平呈正相关关系 (P<0.05) , 与食管通过时间及胃排空时间呈负相关关系 (P<0.05) .甲减与胃动素水平呈负相关关系 (P<0.05) , 与食管通过时间及胃排空时间呈正相关关系 (P<0.05) .结论 甲状腺功能亢进可导致胃肠道功能及胃动素水平升高, 甲状腺功能减退可导致胃肠道功能及胃动素水平下降.

Study on the Relationship between Thyroid Function and Gastrointestinal Motility and Motilinlevels

Objective To analysis the relationship between thyroid function with gastrointestinal motility and plasma motilin levels, and to provide the basis for clinical application.Me thods We selected 30 cases of patients with hyperthyroidism, 30 cases of hyperthyroidism group and hypothyroidism as hypothyroidism group, and 30 healthy volunteers as control group who were treated in our hospital from January 2013 to January 2016 in;The radioimmunoassay was used to test serum motilin levels, isotope single photon emission computed tomography was used to detected the gastric liquid technology half time, esophageal transit time.Re s ults The esophagus passage time of the subjects in the hypothyroidism group was significantly higher than that of the hyperthyroidism group and the control group, and the difference was statistically significant (P<0.05) ;The level of motilin in serum of hyperthyroidism group was significantly higher than that of control group (P<0.05) , and the level of motilin in serum of hypothyroidism group was significantly lower than that of control group (P<0.05) ;Hyperthyroidism was positively correlated with motilin level (r = 0.542, P<0.05) , and negatively correlated with the time of passage of the esophagus and gastric emptying time (r =-0.126 and r =-0.481, P<0.05) ;Hypothyroidism was negatively correlated with motilin level (r =-0.617, P<0.05) , and positively correlated with esophageal transit time and gastric emptying time (r = 0.627 and r = 0.416, P <0.05) .Conclus ions Hyperthyroidism can lead to the increase of gastrointestinal function and motilin level. Hypothyroidism can lead to the decrease of gastrointestinal function and motilin level.