骨碎补总黄酮对骨质疏松症患者牙槽骨的影响

目的: 研究骨碎补总黄酮对合并牙列缺损或缺失的骨质疏松症患者牙槽骨高度、厚度、骨密度及牙槽嵴顶宽度的影响。方法: 将符合纳入标准的46例患者随机分为实验组和对照组,每组23例,实验组服用强骨胶囊,对照组服用阿仑膦酸钠片;于药物治疗前及治疗后1、3、6个月时分别行锥形束CT（CBCT）检查,应用Anatomage invivo 5软件测量并观察牙槽骨高度、厚度、骨密度及牙槽嵴顶宽度的变化,采用SPSS17.0软件包进行统计学分析。结果: 对照组牙槽骨颊(唇)侧皮质骨的骨密度在药物治疗后1个月时较实验组显著升高（P<0.05）,实验组牙槽骨的颊（唇）侧皮质骨骨密度在药物治疗后3个月和6个月时均较对照组显著升高（P<0.05）。对照组牙槽嵴顶宽度和牙槽骨的颊（唇）侧皮质骨厚度在药物治疗后3个月较实验组显著升高（P<0.05）,在药物治疗后6个月时,2组间差异无统计学意义（P>0.05）。不同时点实验组和对照组在基骨的颊（唇）侧皮质骨、松质骨、腭（舌）侧皮质骨的厚度变化均无显著差异（P>0.05）。结论: 骨碎补总黄酮能显著增加骨质疏松症患者牙槽骨骨密度,在增加牙槽骨的颊（唇）侧皮质骨的骨密度上较阿仑膦酸钠存在优势;骨碎补总黄酮能增加骨质疏松症患者牙槽骨的颊（唇）侧皮质骨厚度,对牙槽嵴顶宽度、牙槽骨高度影响不大。

Effect of rhizoma drynariae flavones on alveolar bone quality in patients with osteoporosis

PURPOSE: To evaluate the influence of rhizoma drynariae flavones on the height, thickness, bone mineral density of alveolar bone and width of the alveolar crest for osteoporosis patients with dentition defect or edentulous jaw. METHODS: Forty-six patients who met the inclusion criteria were randomly divided into 2 groups, the experimental group and the control group, 23 cases in each group. Cone-beam CT was performed for each patient before administration and 1 month, 3 months and 6 months after administration, respectively. Anatomage invivo 5 software was used to measure and observe the changes of alveolar bone height, thickness, bone mineral density and alveolar crest width. SPSS 17.0 software package was used for statistical analysis. RESULTS: In the control group, bone mineral density of cortical bone in the buccal (labial) side of the alveolar bone was significantly higher than that of the experimental group 1 months after administration (P<0.05). In the experimental group, bone mineral density of the buccal (labial) cortical bone was significantly higher than that of the control group 3 and 6 months after administration (P<0.05). Compared with the experimental group, the width of the alveolar crest and the thickness of cortical bone in the buccal (labial) side of the alveolar bone increased significantly 3 months after administration in the control group(P<0.05), yet there was no significant difference between the 2 groups at the end of 6 months (P>0.05). No significant difference was found on the thickness of cortical bone in the buccal (labial) side, cortical bone in the palatal(lingual) side and cancellous bone of the basal bone between the 2 groups at different time points (P>0.05). CONCLUSIONS: Rhizoma drynariae flavones can significantly increase bone mineral density of the alveolar bone in osteoporosis patients, which is superior to that of alendronate in increasing bone mineral density of cortical bone in the buccal (labial) side of the alveolar bone. Furthermore, rhizoma drynariae flavones can increase the thickness of cortical bone in the buccal (labial) side of the alveolar bone in patients with osteoporosis, but it has little effect on the width of alveolar crest and the height of alveolar bone.