遗传因素在豫北地区食管癌中的作用分析

目的:分析比较豫北地区食管癌病人家族遗传方面的差异，探讨遗传因素在食管癌中的作用，为食管癌的预防和治疗提供依据。方法:分析2016年1月至2017年3月我院400例食管癌病例，比较豫北地区食管癌遗传度与全国其他高发区遗传度的差异，以及豫北地区有食管癌家族史的病人与无家族史的病人发病年龄、病理分期的差异。结果:有食管癌家族史的病人较无家族史病人普遍发病年龄偏早，恶性程度偏高，预后相对较差。结论:有食管癌家族史的人应列为高危人群，重点监测，定期检查，尽早采取干预措施，减少食管癌的发生。

Analysis of the role of genetic factors in esophageal carcinoma in north Henan

Objective:To analyze the family genetic differences of esophageal carcinoma patients in north Henan province，to prove the role of genetic factor in esophageal carcinoma，and to provide evidence for the prevention and treatment of esophageal carcinoma.Methods:A case-analysis including 400 cases of esophageal carcinoma from January 2016 to March 2017 in our hospital was made.The genetic degree differences of esophageal carcinoma between the north Henan and other high incidence areas of China and the differences in onset age and pathological stage between patients with a family history of esophageal carcinoma and those without a family history are compared.Results:Compared with patients without a family history of esophageal carcinoma，those with a family history were more likely to have an earlier age，a higher degree of malignancy and a relatively poorer prognosis.Conclusion:People with a family history of esophageal carcinoma should be classified as high-risk groups，be monitored emphatically and be checked regularly，and early intervention measures should be taken to reduce the incidence of esophageal carcinoma.