| 血管紧张素受体AT1R与肿瘤血管形成关系的研究进展 |
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| 引用本文： | 崔翼菲1,雨 山2,李子安2,焦宇飞1. 血管紧张素受体AT1R与肿瘤血管形成关系的研究进展[J]. 现代肿瘤医学, 2018, 0(8): 1314-1318. DOI: 10.3969/j.issn.1672-4992.2018.08.042 |
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| 作者姓名： | 崔翼菲1 雨 山2 李子安2 焦宇飞1 |
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| 作者单位： | 1.哈尔滨医科大学附属第二医院病理科，黑龙江 哈尔滨 150000；2.澳门大学健康科学学院，澳门 999078 |
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| 摘 要： | 肾素血管紧张素系统(renin-angiotensin-system,RAS)主要的生理作用是维持心血管功能稳态、电解质和体液平衡、调节血压，但是在一些恶性肿瘤中发现其局部活化。血管紧张素II是肾素血管紧张素系统中重要的成分，在肿瘤的生长、转移、血管的生成过程中发挥关键作用。在不同的肿瘤中可通过与血管紧张素II型1受体(angiotensin II type 1 receptor,AT1R)结合，激活相关信号通路引起血管生成相关因子的升高，促进血管生成，加速肿瘤进展。而AT1R的拮抗剂又能明显抑制或逆转这种生物效应，这些结果提示着AT1R将可能会成为肿瘤治疗新的分子靶点。
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| 关 键 词： | AT1R 血管生成 VEGF RAS 血管紧张素II |
Progress in study of the relationship between AT1R and tumor angiogenesis |
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| Cui Yifei1,Yu Shan2,Li Zian2,Jiao Yufei1. Progress in study of the relationship between AT1R and tumor angiogenesis[J]. Journal of Modern Oncology, 2018, 0(8): 1314-1318. DOI: 10.3969/j.issn.1672-4992.2018.08.042 |
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| Authors: | Cui Yifei1 Yu Shan2 Li Zian2 Jiao Yufei1 |
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| Affiliation: | 1.Department of Pathology,The Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China;2.Faculty of Health Science,University of Macau,Macau 999078,China. |
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| Abstract: | The renin-angiotensin system (renin-angiotensin-system,RAS) the main physiological function is the maintenance of cardiovascular homeostasis,electrolyte and fluid balance,regulating blood pressure,but in some malignant tumors found in the local activation.Angiotensin II plays an important role in the process of tumor growth and metastasis.By combining with AT1R (Angiotensin II type 1 Receptor,AT1 receptor) in different tumors,the activation of related signal pathways can lead to the increase of angiogenesis related factors,promote angiogenesis,and accelerate tumor progression.However,AT1R antagonists can significantly inhibit or reverse this biological effect,which suggests that AT1R may be a new molecular target for cancer therapy. |
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| Keywords: | AT1R angiogenesis VEGF RAS angiotensin II |
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