晚期肺癌并发多器官功能障碍综合征患者急救预后的影响因素

目的:探讨晚期肺癌并发多器官功能障碍综合征（MODS）患者急救预后的影响因素。方法:选取我院于2014年1月至2017年1月期间收治的晚期肺癌并发MODS患者96例，按照患者入院28 d预后情况分为生存组（n=37）与死亡组（n=59例）。均于入院后采用综合治疗，且调查患者一般资料包括性别、年龄、APACHE II评分、MODS评分、器官衰竭数目、C反应蛋白（CRP）、氧合指数、乳酸、血小板、白细胞计数、慢性病史。结果:单因素分析，两组性别、慢性病史比较无统计学差异（P>0.05）；而两组器官衰竭数目比较具有统计学差异（P＜0.05）。单因素分析，两组APACHE II评分、MODS评分、CRP、乳酸及血小板计数比较具有统计学差异（P＜0.05），且生存组APACHE II评分、MODS评分、CRP、乳酸及血小板计数均低于死亡组，具有统计学差异（P＜0.05）；而两组氧合指数和白细胞计数比较无统计学差异（P>0.05）。将上述单因素分析具有统计学差异的纳入多因素分析，器官衰竭数目、APACHE II评分、MODS评分和乳酸为影响预后的独立危险因素。结论:晚期肺癌并发MODS患者急救预后的影响因素中，器官衰竭数目、APACHE II评分、MODS评分和乳酸为其独立危险因素。

Analysis of influential factors of first aid prognosis in patients with advanced lung cancer complicated with multiple organ dysfunction syndrome

Objective:To investigate the influencing factors of first aid prognosis in patients with advanced lung cancer complicated with multiple organ dysfunction syndrome(MODS).Methods:96 patients with advanced lung cancer complicated with MODS were enrolled in our hospital from January 2014 to January 2017，and were divided into survival group(n=37) and death group(n=59).All patients underwent comprehensive treatment.General information included gender，age，APACHE II score，MODS score，number of organ failure，C-reactive protein(CRP)，oxygenation index，platelet，Lac，white blood cell count，chronic history.Results:There was no significant difference in gender and chronic history between the two groups(P＞0.05).There was significant difference in the number of organ failure between the two groups(P＜0.05).The APACHE II score，MODS score，CRP，platelet and Lac in the survival group were lower than those in the death group(P＜0.05).The APACHE II score，MODS score，CRP，platelet and Lac were statistically different(P＜0.05).There was no significant difference in the oxygenation index and white blood cell count between the two groups(P>0.05).The above univariate analysis was statistically different from the included multivariate analysis，the number of organ failure，the APACHE II score，the MODS score and Lac were independent prognostic factors for prognosis.Conclusion:The number of organ failure，APACHE II score，MODS score and Lac were the independent risk factors in the prognostic factors of first aid prognosis in patients with advanced lung cancer.