| B7-H3在恶性肿瘤中的研究进展 |
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| 引用本文： | 王茗典,张大昕. B7-H3在恶性肿瘤中的研究进展[J]. 现代肿瘤医学, 2018, 0(14): 2305-2308. DOI: 10.3969/j.issn.1672-4992.2018.14.041 |
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| 作者姓名： | 王茗典 张大昕 |
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| 作者单位： | 哈尔滨医科大学附属第一医院肿瘤科，黑龙江 哈尔滨 150001 |
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| 摘 要： | B7-H3（CD276）是B7和CD28家族重要的免疫检查点成员，在多种恶性肿瘤中均有表达，并且与恶性肿瘤的生长、转移、复发、预后不良等因素密切相关，与此同时还通过T细胞参与恶性肿瘤的免疫过程。近年来随着研究的深入，人们发现B7-H3在恶性肿瘤中不但是一种共刺激分子，而且对调节性T细胞（regulatory cells,Treg）具有共抑制作用。虽然目前尚未确定它的受体部分，但其分子靶点被认为是一种具有前景的免疫治疗研究方向。本文就B7-H3在恶性肿瘤中的研究进展作一综述。
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| 关 键 词： | B7-H3 恶性肿瘤 免疫治疗 |
Research progress of B7-H3 in malignant tumor |
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| Wang Mingdian,Zhang Daxin. Research progress of B7-H3 in malignant tumor[J]. Journal of Modern Oncology, 2018, 0(14): 2305-2308. DOI: 10.3969/j.issn.1672-4992.2018.14.041 |
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| Authors: | Wang Mingdian Zhang Daxin |
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| Affiliation: | Department of Oncology,First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China. |
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| Abstract: | B7-H3 is a crucial member of immune checkpoint in B7 and CD28 family.It is expressed in many kinds of malignant neoplasms and related to the gross,metastasis,prospective recurrence and poor diagnosis of cancer.Besides,B7-H3 can take part in the immune process of malignant tumor through regulatory T cells.Recent years,with the further research,we found that B7-H3 is not only a kind of costimulus molecular but also plays a coinhibition role in regulatory cells (Treg) in the progression of cancer.Though we are not sure about the receptor of B7-H3,but it is considered to be a promising direction of immunotherapy.This review will conclude the advances of B7-H3 in malignant tumor. |
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| Keywords: | B7-H3 malignant tumor immunotherapy |
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