短程三联疗法联合心理干预对幽门螺杆菌阳性功能性消化不良的疗效观察

目的：利用功能性消化不良医生报告结局量表对短程三联疗法联合心理干预治疗幽门螺杆菌（Hp）阳性功能性消化不良（FD）的临床疗效进行评估，为治疗该病提供临床依据。方法：选择2016年5月至2017年4月我院门诊就诊的120例Hp阳性FD患者作为研究对象，按照随机数字表法分为对照组与观察组，各60例。对照组给予抗Hp短程三联疗法，观察组则在其基础上加入心理干预。比较两组患者功能性消化不良医生报告结局量表评分（CRO）、临床疗效、Hp根除率、不良反应发生率、Zung式焦虑自评量表（SAS）及Zung式抑郁自评量表（SDS）评分的差异。结果：治疗前，两组患者CRO评分比较，差异无显著性（P>0.05）；治疗后，观察组CRO评分明显小于对照组，差异有显著性（P<0.05）。观察组总有效率为86.67%，对照组为83.33%，两组比较差异无显著性（P>0.05），但观察组的显效率更高。观察组Hp根除率为61.67%；对照组为58.33%，两组比较差异无显著性（P>0.05）。观察组不良反应发生率为5.0%，对照组为16.67%，两组比较差异有显著性（P<0.05）。治疗前，两组患者的SAS、SDS评分比较差异无显著性（P>0.05）；治疗后，观察组SAS、SDS评分明显小于对照组，差异有显著性（P<0.05）。结论：短程三联疗法联合心理干预应用于Hp阳性FD患者临床疗效确切，有助于提升患者临床症状缓解效率，降低不良反应发生，具有进一步大样本、多指标研究的价值。

Effect of short term triple therapy combined with psychological intervention on Helicobacter pylori positive functional dyspepsia

OBJECTIVE To evaluate the clinical efficacy of short term triple therapy combined with psychological intervention for the treatment of Helicobacter pylori (Hp) positive functional dyspepsia (FD) utilizing the outcome scale reported by functional dyspepsia doctors, to provide a clinical basis for the treatment of the disease. METHODS A total of 120 patients with Hp positive FD treated in our hospital from May 2016 to April 2017 were selected and divided into control group and observation group according to the random number table method, 60 cases in each group. Patients in the control group were given anti-Hp short term triple therapy, while additional psychological intervention was added for patients in the observation group. Comparing the two groups of patients with functional dyspepsia, the doctors reported differences in outcome score (CRO), clinical efficacy, Hp eradication rate, incidence of adverse reactions, Zung self-rating anxiety scale (SAS) and Zung depression self-rating scale (SDS). RESULTS Before treatment, there was no significant difference in CRO scores between the two groups (P>0.05). After treatment, the CRO score of the observation group was significantly lower than that of the control group (P<0.05). The total effective rate was 86.67% in the observation group and 83.33% in the control group (P>0.05), though the effective rate in the observation group was higher. The HP eradication rate was 61.67% in the observation group and 58.33% in the control group. The incidence of adverse reactions was 5.0% in the observation group and 16.67% in the control group (P<0.05). There was no significant difference in SDS score between the two groups (P>0.05). After treatment, the SDS score of the observation group was significantly lower than that of the control group (P<0.05). CONCLUSION Short term triple therapy combined with psychological intervention is effective in patients with HP positive FD. It is helpful to improve the efficiency of clinical symptom relief and reduce the incidence of adverse reactions, which has the value of further large sample and multi-index research.