Mcl-1和Caspase-3在前列腺癌患者中的表达和意义及相关性分析

目的 观察Mcl-1和Caspase-3在前列腺癌（PCa）、良性前列腺增生（BPH）组织中的表达情况，探讨两者相关性及意义。方法 采用免疫组化法检测并比较分析30例BPH和35例不同病理分级的PCa组织切片Mcl-1、Caspase-3蛋白的表达。结果 PCa组Mcl-1阳性表达率为82.86%（29/35），显著高于BPH组13.33%（4/30,P<0.05）；PCa组Caspase-3阳性表达率为25.71%（9/35），显著低于BPH组73.33%（22/30）（P<0.05）。Mcl-1、Caspase-3蛋白的表达与PCa患者术前PSA值、有无远处转移、Gleason评分、临床分期等临床资料无关(P>0.05)。在PCa组织中Mcl-1的表达与Caspase-3的表达呈负相关（r_s=-0.748，P<0.05）。结论Mcl-1、Caspase-3在PCa的发生、发展中可能相互影响。

Expressions and significance of Mcl-1 and Caspase-3 and theirs correlation in tissues of prostate cancer

Objective  To study the relationship of the expressions of Mcl-1 and Caspase-3 in tissues of prostate cancer(PCa) and benign prostatic hyperplasia (BPH), investigate the correlation of Mcl-l and Caspase-3.Methods  The expressions of Mcl-1 and Caspase-3 were observed separately in 30 of BPH, and 35 of PCa by means of immunohistochemical methods. Results  Mcl-1 positive rate in BPH was 13.33%（4/30）, and in PCa was 82.86%（29/35）. Caspase-3 positive rate in BPH was 73.33%（22/30）, and in PCa was 25.71%（9/35）. Expression of Mcl-1 and Caspase-3 in PCa was unrelated with preperative PSA, distant metastases, Gleason score and clincal stage(P>0.05). There was a negative relationship between the expression of Mcl-1 and Caspase-3 in tissues of PCa（r_s=-0.748, P<0.05）.Conclusions  The expression of Mcl-1 is raised while the expression of Caspase-3 is low in PCa tissue, showing that they may have a common mechanism in the process of apoptosis.