| 神经炎症与糖尿病视网膜病变 |
| |
| 引用本文： | 薛盛丁,俞莹,陈辉.神经炎症与糖尿病视网膜病变[J].国际眼科纵览,2018,42(3):153. |
| |
| 作者姓名： | 薛盛丁 俞莹 陈辉 |
| |
| 作者单位： | 226000.南通大学附属医院眼科 |
| |
| 基金项目： | 国家自然科学基金（81700853） |
| |
| 摘 要： | 糖尿病视网膜病变（diabetic retinopathy, DR）是高血糖引起的视网膜血管病变，神经炎症在DR的发病过程中起重要作用。在高糖环境下视网膜神经胶质细胞和神经元可释放各种炎性介质，炎性介质水平上调可引起糖尿病患者视网膜的神经炎性反应。而在眼底微血管病变之前就有神经视网膜的电生理改变，因此神经炎症可能成为防治DR的新的药物靶点。抑制神经炎症相关的药物有：米诺环素、橙皮素、大麻二酚、阿司匹林和水杨酸、醛糖还原酶抑制剂等。（国际眼科纵览， 2018, 42: 153-158）
|
| 收稿时间： | 2018-01-25 |
Neurological inflammation and diabetic retinopathy |
| |
| XUE Sheng-ding,YU Ying,CHEN Hui.Neurological inflammation and diabetic retinopathy[J].International Review of Opthalmology,2018,42(3):153. |
| |
| Authors: | XUE Sheng-ding YU Ying CHEN Hui |
| |
| Institution: | Department of Ophthalmology, the Affiliated Hospital of Nantong University, Nantong 226000, China |
| |
| Abstract: | Diabetic retinopathy (DR) is a retinal vascular disease caused by hyperglycemia. Neuroinflammation plays an important role in the pathogenesis of DR. In the hyperglycemic environment, some retina glial cells and neurons can release various inflammatory mediators, causing the up-regulation of inflammatory mediators, thus causing retina neuroinflammation in diabetic patients. Electrophysiological changes in the neuroretina happen prior to fundus microvascular lesion, suggesting neuroinflammation may become a new drug target for the prevention and treatment of DR. Drugs that inhibit neuroinflammation include minocycline, hesperetin, cannabidiol, aspirin and salicylate, aldose reductase inhibitors and so on. (Int Rev Ophthalmol, 2018, 42: 153-158) |
| |
| Keywords: | |
|
| 点击此处可从《国际眼科纵览》浏览原始摘要信息 |
| 点击此处可从《国际眼科纵览》下载免费的PDF全文 |
|
