内复制及其在肿瘤发生发展中的作用 |
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引用本文: | 齐丽莎,王靖怡,王雅蕾,刘志勇,曹文枫. 内复制及其在肿瘤发生发展中的作用[J]. 中国肿瘤临床, 2018, 45(20): 1071-1074. DOI: 10.3969/j.issn.1000-8179.2018.20.885 |
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作者姓名: | 齐丽莎 王靖怡 王雅蕾 刘志勇 曹文枫 |
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作者单位: | 天津医科大学肿瘤医院病理科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津市恶性肿瘤临床医学研究中心(天津市300060) |
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基金项目: | 国家自然科学基金81402420天津市应用基础与前沿技术研究计划青年项目15JCQNJC12400天津市卫生计生委重点攻关项目16KG125 |
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摘 要: | 大多数的二倍体细胞通常通过G1期(DNA合成前期)、S期(DNA合成期)、G2期(DNA合成后期)和M期(分裂期)经典细胞周期完成细胞增殖。然而,在动、植物中也广泛存在着一种与有丝分裂不同的细胞周期过程,即内复制。在内复制过程中,G期和S期交替出现,细胞并不发生分裂,导致产生多倍体细胞。内复制在人体的正常发育、器官形成、创伤愈合过程中必不可少。近年来,越来越多的研究关注内复制与肿瘤发生、演进的关系。本文就内复制的生理作用做一概述,并讨论内复制在肿瘤发生、发展中的可能作用及相关分子机制。
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关 键 词: | 内复制 细胞周期 多倍体巨细胞 肿瘤 |
收稿时间: | 2018-08-30 |
Endoreplication and its role in tumor development and progression |
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Affiliation: | Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China |
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Abstract: | Most diploid cells proliferate by proceeding through the canonical G1 (DNA pre-synthesis), S (DNA synthesis), G2 (DNA postsynthesis), and M(mitosis) phases of the cell cycle. However, there is another type of cell cycle that occurs frequently in both plants and animals, known as endoreplication. Endoreplication consists of alternating periods of G and S phases without cytokinesis, which results in polyploidy. It is indispensable for normal development, organ formation, and wound healing in humans. In recent years, considerable attention has been paid to delineating the connections of endoreplication with tumorigenesis and tumor progression. Here, we review the role of endoreplication in normal human development and discuss its possible role in tumor development and the underlying molecular mechanisms. |
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