| 用体外释放度优选硝酸咪康唑缓释凝胶基质的研究 |
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| 引用本文： | 邢树礼,徐燕平,李宁,程永佳,高行,王春伟,高新富,孙迎东. 用体外释放度优选硝酸咪康唑缓释凝胶基质的研究[J]. 中国医院药学杂志, 2018, 38(8): 835-837. DOI: 10.13286/j.cnki.chinhosppharmacyj.2018.08.07 |
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| 作者姓名： | 邢树礼 徐燕平 李宁 程永佳 高行 王春伟 高新富 孙迎东 |
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| 作者单位： | 1. 滨州医学院附属医院, 山东 滨州 256600;2. 滨州市人民医院, 山东 滨州 256609 |
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| 基金项目： | 滨州市科技发展计划项目（编号：2015ZC0310；2014ZC0141）；山东省医药卫生科技发展计划项目（编号：2016WS0050）；滨州医学院科技计划（编号：BY2011KJ026） |
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| 摘 要： | 目的：优选硝酸咪康唑缓释凝胶剂的处方。方法：采用正交设计法，以聚卡波菲、甘油、山嵛酸甘油酯的用量为因素，以累积释放度作为考查指标，对硝酸咪康唑缓释凝胶剂的处方进行优选。结果：优选的凝胶剂最佳处方为聚卡波菲1.5 g、甘油5 mL、山嵛酸甘油酯2.0 g。结论：体外累积释放试验筛选硝酸咪康唑凝胶剂处方可行，所得缓释凝胶的质量符合2015年版《中国药典》有关规定。
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| 关 键 词： | 体外释放度 正交设计法 硝酸咪康唑 缓释凝胶 |
| 收稿时间： | 2017-09-30 |
Optimization of the formulation of miconazole nitrate sustained-release gel by release rate in vitro |
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| XING Shu-li,XU Yan-ping,LI Ning,CHENG Yong-jia,GAO Hang,WANG Chun-wei,GAO Xin-fu,SUN Ying-dong. Optimization of the formulation of miconazole nitrate sustained-release gel by release rate in vitro[J]. Chinese Journal of Hospital Pharmacy, 2018, 38(8): 835-837. DOI: 10.13286/j.cnki.chinhosppharmacyj.2018.08.07 |
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| Authors: | XING Shu-li XU Yan-ping LI Ning CHENG Yong-jia GAO Hang WANG Chun-wei GAO Xin-fu SUN Ying-dong |
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| Affiliation: | 1. Binzhou Medical University Hospital, Shandong Binzhou 256600, China;2. Binzhou People's Hospital, Shandong Binzhou 256609, China |
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| Abstract: | OBJECTIVE To optimize the formulation of miconazole nitrate sustained-release gel.METHODS The orthogonal design method was adopted. The amounts of polycarbophil, glycerin and compritol 888 ATO were used as analysis factors, and sustained-release was used as test index.RESULTS The optimal formulation of itraconazole gels was polycarbophil of 1.5 g, glycerin of 5 mL,and compritol 888 ATO of 2.0 g.CONCLUSION The method adopted for screening the formulation of the gels is feasible, and the quality meets the requirements of Pharmacopoeia 2015. |
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| Keywords: | release rate in vitro orthogonal design method miconazole nitrate sustained-release gel |
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