| 微小RNA在免疫性血小板减少症发病机制中的研究进展 |
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| 引用本文： | 赵海丰,阚育田,王鑫源,张翼鷟. 微小RNA在免疫性血小板减少症发病机制中的研究进展[J]. 天津医药, 2018, 46(10): 1131-1134. DOI: 10.11958/20180786 |
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| 作者姓名： | 赵海丰 阚育田 王鑫源 张翼鷟 |
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| 作者单位： | 基金项目：国家自然科学基金资助项目（81100337,81470283,81570201）作者单位：天津医科大学肿瘤医院,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学研究中心（邮编300060）作者简介：赵海丰（1980）,男,博士,副主任医师,副教授,主要从事ITP发病机制的研究△通讯作者 E-mail: yizhuozhang111@163.com |
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| 基金项目： | miR-409-3p 在ITP Th1/Th2 失衡中的作用及机制研究;组蛋白乙酰化修饰在ITP发病中的作用及机制研究;BCR信号通路和c-Myc在肿瘤微环境介导的弥漫大B细胞淋巴瘤化疗耐药中 的协同作用研究 |
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| 摘 要： | 摘要：免疫性血小板减少症（ITP）是由于血小板破坏增加或生成减少导致外周血血小板的减少,引起皮肤、黏膜及内脏出血等临床表现为特点的常见出血性疾病。ITP的发病机制迄今为止尚未得到完全阐明,积极探索本病的发病机制,不仅具有重要的理论意义,而且可能为本病的治疗提供新的策略。微小RNA（microRNA,miRNA）是一类长度约为19~22个核苷酸的小分子非编码RNA,通过调控其靶基因,参与多种疾病的发生和发展。目前miRNA在ITP发病机制中的研究越来越广泛,本文就近年来针对miRNA在ITP发病机制中的研究进展做一综述。
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| 关 键 词： | 血小板减少 微RNAs 免疫性血小板减少症 综述 |
| 收稿时间： | 2018-05-15 |
| 修稿时间： | 2018-07-15 |
The progress of miRNA in the pathogenesis of immune thrombocytopenia |
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| ZHAO Hai-feng,KAN Yu-tian,WANG Xin-yuan,ZHANG Yi-zhuo. The progress of miRNA in the pathogenesis of immune thrombocytopenia[J]. Tianjin Medical Journal, 2018, 46(10): 1131-1134. DOI: 10.11958/20180786 |
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| Authors: | ZHAO Hai-feng KAN Yu-tian WANG Xin-yuan ZHANG Yi-zhuo |
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| Affiliation: | Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory ofCancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China△Corresponding Author E-mail: yizhuozhang111@163.com |
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| Abstract: | Abstract：Immune thrombocytopenia (ITP), one of the most common bleeding disorders, is characterized by clinical manifestations of skin mucosa and internal bleeding and by decreased platelet count due to auto-antibody mediating theplatelets destruction and insufficient platelet production. The exact etiology of ITP is still unclear so far. To fully understandthe pathogenesis of ITP not only has important theoretical significance but also may provide a new strategy for the treatmentof the disease. MicroRNA (miRNA) is a class of small non-coding RNAs with a length of 19-22 nucleotides. It is involved inthe occurrence and development of many diseases by regulating its target genes. At present, there are more and more studieson the role of microRNAs in the pathogenesis of ITP. In this review, the progress of miRNA in the pathogenesis of ITP inrecent years was summarized |
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| Keywords: | thrombocytopenia MicroRNAs immune thrombocytopenia review |
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