甘氨双唑钠对老年局部晚期宫颈癌患者放射治疗增敏作用的临床研究

目的:探讨注射用甘氨双唑钠(希美纳)对于老年局部晚期宫颈癌患者的放射增敏作用及不良反应。方法:选择老年宫颈癌患者50例，FIGO分期为Ⅰb2-Ⅳ期，按是否应用放射增敏剂，分为试验组(放疗加甘氨双唑钠)和对照组(单纯放疗)。试验组患者放疗前使用甘氨双唑钠(希美纳)800 mg/m2，给药后 1 h内接受放疗，每周3次，连续用药至放疗结束。两组放疗均为盆腔三维适形或调强放疗加后装放疗。放疗前、外照射结束和放疗结束后1月，观察疗效和不良反应。结果:试验组完全缓解（CR）率高达83.33%，明显高于对照组的55.00%，差异有统计学意义(P＜0.05)。试验组与对照组1年的总生存率（OS）均为100%，2年OS分别为:95.24%、92.31%，1年PFS分别为:96.29%、94.73%，2年无进展生存率（PFS）分别为:89.87%、73.08%，经Long-rank检验分析，其P＞0.05，两组差异无统计学意义。两组患者不良反应发生率比较，差异无统计学意义(P＞0.05)。结论:注射用甘氨双唑钠可提高老年局部晚期宫颈癌患者的近期CR，同时未增加不良反应，但2年的OS及PFS尚无差异，其远期疗效及不良反应仍有待进一步观察。

Therapeutic effect of sodium glycididazole combined with radiotherapy on the aged locoregionally advanced cervical cancer

Objective:To observe clinically therapeutic effect and adverse reaction of CM-Na( sodium glycididazole) combined with radiotherapy on the aged locoregionally advanced cervical cancer(ADCC)．Methods:Fifty cases of ADCC in FIGO stage Ib2-Ⅳ were divided into trial group(n=30,CM-Na plus radiotherapy) and control group(n=20,radiotherapy)．The trial group was treated with CM-Na(800 mg /m2 in 100 ml normal saline iv within 30 min on monday，wednesday and friday every week till the end of the radiotherapy，after which radiotherapy was administered within 60 min)．The control group only took radiotherapy.To observe therapeutic effect and adverse reaction of two groups.Results:Complete respond rate(CR) of the trial group was higher than that of the control group's． The differences in CR were statistically significant(P＜0.05) between the two groups．The 1-,2-year OS rates of trial group were 100％,95.24％，and the rates in control group were 100％,92.31％,with no statistical difference(P＞0.05).The 1-,2-,year PFS rates of trial group were 96.29%，89.87%，and the rates in control group were 94.73%,73.08%,but with no statistical difference(P＞0.05).The adverse reaction incidence was of no significant difference between the two groups(P＞0.05).Conclusion:Compared the only radiotherapy group,CM-Na combined with radiotherapy for ADCC may improve the overall complete remission rate without an increase in toxicity．However,its long-term effect remains to be further studies.