基质金属蛋白酶-7启动子（-181A/G）基因多态性与消化道肿瘤易感性的Meta分析

目的:评价基质金属蛋白酶-7（MMP-7）启动子（-181A/G）基因多态性与消化道肿瘤易感性的关系。方法:计算机检索各大医学数据库，对2017年7月前公开发表的关于MMP-7（-181A/G）基因多态性的病例对照研究进行Meta分析。结果:共19项研究符合纳入标准，累计病例数3 296例，对照组4 362例。从总体效应量分析，除隐性基因模型外，MMP-7（-181A/G）基因多态性与消化道肿瘤易感性有关，差异有统计学意义（G vs A,OR=1.25,95%CI:1.09~1.43,P=0.00;GG/AG vs AA,OR=1.25,95%CI:1.12~1.39,P=0.00;GG vs AA,OR=1.42,95%CI:1.03~1.94,P=0.03;AG vs AA,OR=1.21,95%CI:1.07~1.35,P=0.00）。进一步分层分析表明MMP-7（-181A/G）基因多态性与胃癌、食管鳞癌的易感性有关，但并不能确定是否增加结直肠癌的发生风险。按照种族进行亚组分析，提示MMP-7（-181A/G）基因多态性能够显著增加亚洲人群的消化道肿瘤的发生率。结论:MMP-7（-181A/G）基因多态性与消化道肿瘤有关，G等位基因增加了食管鳞癌、胃癌的发生风险。

Association between promoter polymorphisms of matrix metalloproteinases-7(-181A/G) and risk of digestive cancers:A Meta-analysis

Objective:To explore the association between of MMP-7 gene polymorphism and digestive cancer susceptibility.Methods:Data bases were comprehensively searched to retrieve all related data,Meta-analysis of case-control studies on the association between MMP-7 gene polymorphism and digestive cancer in published up to July 2017.Results:19 original studies fulfilled the inclusion criteria with a total of 3 296 patients and 4 362 controls entered into study dataset.Meta-analysis showed that the significant association between MMP-7（-181A/G）polymorphism and digestive cancer was found under the allele model（G vs A,OR=1.25,95%CI:1.09~1.43,P=0.00),dominant model（GG/AG vs AA,OR=1.25,95%CI:1.12~1.39,P=0.00),homozygous model(GG vs AA,OR=1.42,95%CI:1.03~1.94,P=0.03),heterozygous model(AG vs AA,OR=1.21,95%CI:1.07~1.35,P=0.00) except for recessive model（GG vs AG/AA,OR=1.30,95%CI:0.96~1.76).Further stratification analysis showed that MMP-7(-181A/G) polymorphism was associated with susceptibility to gastric cancer and esophageal cancer,but it was not possible to determine the risk of colorectal cancer.Subgroup analysis by ethnicity suggested that MMP-7（-181A/G) gene polymorphisms can significantly increase the incidence of digestive cancers in the Asian population.Conclusion:This Meta-analysis demonstrated that MMP-7（-181A/G) polymorphism was associated with digestive cancers,and the G allele may increases the risk of esophageal and gastric cancer.