肿瘤靶向治疗的心血管毒性研究进展肿瘤靶向治疗的心血管毒性研究进展

靶向治疗是选择性作用于肿瘤发生中关键分子的新型抗肿瘤治疗策略。由于最大限度减少了正常细胞的损伤，其与化疗相比具有高效低毒的优势。然而，近年来靶向治疗导致的心血管毒性严重影响患者的预后，因而得到越来越多的重视与关注。临床常见靶向药物的心血管毒性包括心力衰竭、高血压、心律失常、血栓形成等。绝大部分心血管毒性的发生机制仍不是很清楚。在治疗基线完善心血管检查并后续进行密切随访和管理，对常见心血管毒性进行早期预防监测并及早干预对于心脏毒性的防治具有重要意义。

Advances in cardiovascular toxicities induced by cancer targeted therapy

Targeted therapy is a novel strategy in which key molecules in signaling pathways involved in carcinogenesis are inhibited.Targeted cancer therapy has fewer adverse effects on normal cells and is considered to be the future of chemotherapy.However,cardiovascular toxicities are occasionally critical issues in patients who receive targeted therapy.The most common cardiovascular toxicities of targeted therapy include heart failure,hypertension,arrhythmia,thrombogenesis and so on.The mechanism of cardiovascular toxicity is unclear.Follow-up and management at baseline about cardiac function,early diagnosis and treatment can help reduce the incidence of cardiovascular toxicity.