多中心型Castleman病临床病理分析并文献复习

目的:探讨多中心型Castleman病（multiple Castleman disease,MCD）的临床表现、病理学特征、鉴别诊断、病因及治疗，并分析其预后。方法:对9例多中心型Castleman病的临床资料、病理形态学特征进行分析，并行免疫组化检测及相关文献复习。结果:9例多中心型Castleman病例中，透明血管型5例，浆细胞型2例，透明血管浆细胞混合型2例。免疫组化无特征性表现，但可辅助诊断及鉴别诊断。9例多中心型患者均有完整随访资料，经治疗后其中有1例复发，1例死于心脏疾病，其余患者症状均有所缓解。结论:多中心型Castleman病是一种少见的淋巴组织增生性疾病，临床易与其他疾病相混淆，确诊需依靠病理学检查，准确的临床分型和病理类型对患者的治疗和预后具有重要意义。

Clinicopathologic analysis of multicentric Castleman disease and review of the literature

Objective:To investigate the clinic-pathologic features，differential diagnosis,etiology,treatment of multicentric Castleman disease，and analyze their prognosis.Methods:Retrospective analysis of the clinical features，pathological morphology,immunohistochemistry were conducted in 9 cases of multicentric Castleman disease and reviewed of literature．Results:There were 5 cases of hayline vascular types，2 cases of plasmatcyic type and 2 cases of mixed type in all multicentric Castleman disease． Immunohistochemical results had not specific change，but they can assist diagnosis and differential diagnosis.9 cases had complete follow-up data,1 case recurrened after treatment，1 case died of heart disease,other multicentric cases achieved sustained remission.Conclusion:Multicentric Castlemandisease is a rare lymphoproliferative lesion，it is easily confused with other diseases,identified diagnosis is depend on pathological examination.The accuracy of clinical subtype and histopathogenic type are important for treatment and outcome.