临床药师促进临床合理应用质子泵抑制剂实践

目的:分析临床药师在促进临床合理应用质子泵抑制剂的干预效果。方法:选取干预前某院住院患者使用质子泵抑制剂病历(2015年4-12月)及临床药师干预后住院患者使用质子泵抑制剂病历(2016年4-12月)各160份,调查对比干预前和干预后质子泵抑制剂不良反应及无适应证用药、遴选药物不适宜、给药途径不适宜、疗程过长、联合用药不适宜、用药重复等情况。结果:干预后质子泵抑制剂不良反应发生率低于干预前,但统计学无差异;干预后无适应证用药、遴选药物不适宜、给药途径不适宜、疗程过长、联合用药不适宜比例均显著低于干预前,差异有统计学意义;干预后用药重复比例有所下降,但统计学无差异。结论:临床药师经过干预临床用药,可以促进临床合理应用质子泵抑制剂。

Rational application of proton pump inhibitors promoted by clinical pharmacists

OBJECTIVE To analyze the intervening effects of clinical pharmacists on promoting clinical rational use of proton pump inhibitors. METHODS Totally 160 medical records with proton pump inhibitors used before intervention from April to December in 2015 and 160 medical records with proton pump inhibitors used after intervention from April to December 2016 were chosen. The adverse reactions, no indications of medication, unsuited selection of drug, inappropriate administration route, long duration of medication treatment, inappropriate drug combination were investigated and analyzed. RESULTS The incidence rate of adverse reaction after intervention was lower than that of non-intervention, but there was no statistical difference. The rates of no indications of medication, unsuited selection of drug, inappropriate administration route, long duration of medication treatment, inappropriate drug combination in intervention group were lower than those of non-intervention group, and the difference was statistically significant. The rate of repeated medication decreased after intervention, but there was no statistical difference. CONCLUSION Clinical pharmacists can help clinical medication to promote clinical reasonable application of proton pump inhibitors.