万古霉素致DRESS综合征22例文献分析

目的:分析万古霉素致伴嗜酸性粒细胞增多和系统症状的药疹综合征(DRESS综合征)的发生规律及特点,为安全用药提供参考。方法:检索国内外库收载的万古霉素致DRESS综合征文献进行分析。结果:共筛选出有效个案报道15篇,22例患者,其中男14例,女8例,青少年2例。用药至发生DRESS综合征的平均时间为3周。临床表现主要为皮疹、发热、嗜酸性粒细胞增多并累及多器官损伤,最常见受累的器官为肝脏(16例,72.7%)。结论:临床医师应了解万古霉素致DRESS综合征的规律和特点,加强用药监测,以便及时发现和处理DRESS综合征。

Analysis of 22 cases of drug rash with eosinophilia and systemic symptoms syndrome by vancomycin based on literature review

OBJECTIVE To analyze the general patterns and characteristics of drug rash with eosinophilia and systemic symptoms syndrome (DRESS) induced by vancomycin and provide a reference for clinical medication. METHODS DRESS of vancomycin reported in domestic and foreign academic journals were collected and analyzed statistically. RESULTS A total of 15 reports involving 22 patients were collected, including 14 men and 8 women. Of 22 cases, there were 2 teenage patients. The average occurrence time of DRESS induced by vancomycin was 3 weeks (range:7 to 34 days). The main clinical manifestations were rash, fever, eosinophilia and multiple organ injury. The most common damaged organ was the liver (n=16, 72.7%). CONCLUSION Clinicians should be aware of rules and characteristics of DRESS induced by vancomycin and tighten monitoring on it to detect and deal with DRESS.