| 粒细胞-巨噬细胞集落刺激因子联合放疗研究进展 |
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| 引用本文： | 张佳奇,赵路军,刘宁波,王平. 粒细胞-巨噬细胞集落刺激因子联合放疗研究进展[J]. 中国肿瘤临床, 2018, 45(9): 468-471. DOI: 10.3969/j.issn.1000-8179.2018.09.294 |
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| 作者姓名： | 张佳奇 赵路军 刘宁波 王平 |
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| 作者单位： | 天津医科大学肿瘤医院放射治疗科，国家肿瘤临床医学研究中心，天津市肿瘤防治重点实验室，天津市恶性肿瘤临床医学研究中心（天津市300060） |
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| 基金项目： | 国家自然科学基金项目81372429 |
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| 摘 要： | 粒细胞-巨噬细胞集落刺激因子（granulocyte-macrophage colony-stimulating factor，GM-CSF）作为一种造血因子可以有效诱导多种具有抑瘤效应的免疫细胞增殖，从而发挥抗肿瘤免疫反应。放疗作为肿瘤治疗的主要手段之一，不仅可以直接杀伤肿瘤细胞，而且会对抗肿瘤免疫产生影响。多项临床研究提示，放疗联合GM-CSF可以诱导产生旁观者效应并增强对肿瘤的远期控制，从而增强放疗的抗肿瘤效应。本文就GM-CSF及GM-CSF联合放疗的研究进展予以综述。
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| 关 键 词： | 粒细胞-巨噬细胞集落刺激因子 放射治疗 免疫 |
| 收稿时间： | 2017-11-21 |
Advances of granulocyte-macrophage colony-stimulating factor combinied with radiotherapy |
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| Affiliation: | Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China |
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| Abstract: | The granulocyte-macrophage colony-stimulating factor (GM-CSF) can effectively induce the proliferation of tumor-associated immunocytes as a hematopoietic factor; therefore, the fact that GM-CSF can induce systemic antitumor immune responses has attracted much attention. Radiotherapy, as one of the main treatment approaches of cancer, can kill tumor cells directly, and has an effect on anti-tumor immunity. Several clinical studies have shown that radiotherapy combined with the GM-CSF can induce an abscopal effect and confer favorable therapeutic effects for cancer. Herein, we review the research progress on GM-CSF, and radiotherapy combined with GM-CSF in tumor treatment. |
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