行湿颗粒联合玉龙散对腰椎间盘突出症的疗效及血清炎症因子的影响

目的：考察行湿颗粒联合玉龙散对腰椎间盘突出症临床疗效及对血清炎症因子的调节作用。方法：将符合纳入标准的320例寒湿证腰椎间盘突出症患者随机分为对照组、玉龙散组、行湿颗粒组、联合用药组，每组80例。各组患者用药治疗2个疗程后，通过对治疗前后临床疗效、JOA腰椎功能评分、VAS疼痛评分、外周血清炎症因子肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、白细胞介素-1β（interleukin-1β，IL-1β）、白细胞介素-6（interleukin-6，IL-6）]的表达水平及用药期间药物不良反应发生情况进行对比分析。结果：联合用药组临床总有效率达92.50%，与对照组相比差异具有显著性（P<0.05）。联合用药组VAS、JOA评分均显著低于其他各组，组间比较差异具有显著性（P<0.05）。联合用药组患者外周血清TNF-α、IL-1β、IL-6的下调作用明显强于对照组，组间比较差异具有显著性（P<0.05）。各组患者用药期间未发生明显不良反应。结论：行湿颗粒联合玉龙散配合常规理疗的治疗方案对LIDH患者能明显减轻患者的疼痛感，还能最大程度地改善腰椎活动状态，其发挥该作用趋势的主要原因可能与玉龙散和行湿颗粒下调血清炎症因子TNF-α、IL-1β、IL-6的表达有关。

Joint yulong line wet particles scattered the clinical curative effect of lumbar intervertebral disc protrusion and the influence of serum inflammatory factors

OBJECTIVE To investigate the clinical effect of the combination of Xingshi particles and Yulong powder on lumbar intervertebral disc herniation (LIDH) and the regulation of serum inflammatory factors.METHODS Will meet the inclusion criteria 320 cases of cold dampness syndrome in patients with LIDH were randomly divided into control group, Yulong powder group, Xingshi particles group and combination group, 80 cases in each group. The treatment group patients after 2 courses of treatment, the clinical curative effect before and after treatment, JOA scores, VAS scores, peripheral serum inflammatory cytokinestumor necrosis factor alpha (TNF-α), interleukin -1β(IL-1β), interleukin -6 (IL-6) and the expression level of the drug during the incidence of adverse drug reactions were compared.RESULTS The total effective rate of combined use group reached 92.50%, compared with the control group, the difference was statistically significant (P<0.05). The down-regulation of TNF-α, IL-1β and IL-6 in peripheral blood of the joint treated group was significantly stronger than that in the control group, and the difference between the two groups was statistically (P<0.05). No obvious adverse reactions occurred during the medication.CONCLUSION The clinical symptoms of treatment for Xingshi particles and Yulong powder combined with conventional therapy for LIDH patients had a positive effect, not only can significantly reduce the pain of patients and improve the lumbar motion state but also to the maximum extent, the main reason to play the role of the trend may be related to the expression of Xingshi particles and Yulong powder down serum inflammatory factor TNF-α, IL-1β, IL-6.