| 肿瘤血管生成拟态在结肠癌中的研究进展 |
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| 引用本文： | 杨 莹,胡 叶,吴 娜,王超然,左明焕. 肿瘤血管生成拟态在结肠癌中的研究进展[J]. 现代肿瘤医学, 2018, 0(1): 149-152. DOI: 10.3969/j.issn.1672-4992.2018.01.039 |
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| 作者姓名： | 杨 莹 胡 叶 吴 娜 王超然 左明焕 |
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| 作者单位： | 北京中医药大学东方医院肿瘤科，北京 100078 |
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| 基金项目： | National Natural Science Foundation of China(No.81373832）；国家自然科学基金资助项目（编号:81373832） |
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| 摘 要： | 血管生成拟态（vasculogenic mimicry,VM）是近年来发现的一种与经典的肿瘤血管生成途径完全不同、不依赖机体内皮细胞的全新肿瘤微循环模式，与肿瘤生长、侵袭、转移及患者预后密切相关。VM可能是一个潜在的肿瘤治疗新靶点，但其形成的分子机制尚未完全清楚。本文就近年来VM在结肠癌中发现、可能分子机制及其对治疗的影响作一综述，探讨当前研究中存在的问题，展望未来的发展方向。
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| 关 键 词： | 血管生成拟态 结肠癌 分子机制 |
Research development of vasculogenic mimicry in colon cancer |
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| Yang Ying,Hu Ye,Wu Na,Wang Chaoran,Zuo Minghuan. Research development of vasculogenic mimicry in colon cancer[J]. Journal of Modern Oncology, 2018, 0(1): 149-152. DOI: 10.3969/j.issn.1672-4992.2018.01.039 |
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| Authors: | Yang Ying Hu Ye Wu Na Wang Chaoran Zuo Minghuan |
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| Affiliation: | Department of Oncology，Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100078，China. |
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| Abstract: | Vasculogenic mimicry (VM) is a new pattern of tumor microcirculation found in recent years，which is totally different from the classic tumor angiogenesis and independent of vascular endothelial cells.Vasculogenic mimicry has close relationship with the growth，invasion，metastases of tumors and the prognosis of patients．VM may be a potentially important new target for cancer treatment，but the molecular mechanism of VM formation remains unclear.In this review，we summarize the characteristics，molecular mechanism，and significance in therapy of vasculogenic mimicry in colon tumor. |
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| Keywords: | vasculogenic mimicry colon cancer molecular mechanism |
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