某院近5年耐碳青霉烯类肺炎克雷伯菌检出情况

目的 了解临床分离耐碳青霉烯类肺炎克雷伯菌 (CRKP) 检出情况, 提出药物治疗策略, 为CRKP医院感染的治疗及预防提供依据.方法 收集某医院2013年至2017年住院患者临床分离的CRKP, 分析其检出率及标本来源分布.结果 2 237株肺炎克雷伯菌中, 检出CRKP 76株 (3.40%) .2013年至2017年CRKP检出率呈逐年上升趋势, 差异有统计学意义 (P<0.01) .CRKP检出率与碳青霉烯类DDDS呈正相关, 差异有统计学意义 (P<0.01) .CRKP感染部位主要为呼吸道和泌尿道, 主要分布于ICU、神经外科和老年医学科.结论CRKP检出率逐年上升, 应引起临床及感控的高度重视.治疗方案多以替加环素或多黏菌素为基础的联合用药.

Analysis on the Detection of Carbapenem-Resistant Klebsiella Pneumonia in a Hospital in Recent 5 Years

Objective To understand the detection of clinically isolated carbapenem-resistant Klebsiella pneumonia (CRKP) , and propose a strategy for drug treatment, so as to provide evidence for treatment and prevention of CRKP nosocomial infections.Me thods The isolated CRKP specimens from inpatients from 2013 to2017 were collected in a local hospital. Detection rate and sources of specimens were analyzed. Re s ults Totally2, 237 strains of Klebsiella pneumonia were detected, and 76 (accounting for 3.40%) were CRKP strains. The detection rate of CRKP from 2013 to 2017 showed an upward trend gradually, and the difference was statistically significant (P <0.01) . A positive correlation was observed between the detection rate of CRKP and DDDS of carbapenems, and the difference was statistically significant (P<0.05) . The main infection of CRKP occurred in respiratory tract and urinary tract, and detection of CRKP was mainly from ICU, neurosurgery and geriatrics departments. Conclus ion CRKP infection increase year by year, which should receive sufficient clinical and infection control attention. Therapy of CRKP infection is mainly based on the combined tigecycline or polymyxin.