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Influence of birthplace on gastroschisis outcomes in a state in the southeastern region of Brazil
Affiliation:1. Universidade Federal do Espírito Santo (UFES), Programa de Pós-Graduação em Saúde Coletiva, Vitória, ES, Brazil;2. Sociedade Brasileira de Pediatria (SBP), Especialista em Neonatologia, Brazil;3. Secretaria de Estado da Saúde do Espírito Santo (SESA-ES), Hospital Estadual Infantil Nossa Senhora da Glória (HEINSG), Núcleo de Terapia Intensiva Pediátrica e Neonatologia, Vitória, ES, Brazil;4. Universidade Federal do Espírito Santo (UFES), Saúde Coletiva, Vitória, ES, Brazil;5. Associação de Medicina Intensiva Brasileira (AMIB/SBP), Especialista em Medicina Intensiva Pediátrica, Brazil;6. Universidade Estadual de Campinas (UNICAMP), Biologia Patologia Buco Dental, Campinas, SP, Brazil;7. Hospital Estadual e Maternidade Alzir Bernadino Alves (HEIMABA), Cooperativa dos Cirurgiões Pediátricos do Espírito Santo (Coopercipes), Vila Velha, ES, Brazil;8. Hospital Estadual Dr. Jayme Santos Neves (HEJSN), Cooperativa dos Cirurgiões Pediátricos do Espírito Santo (Coopercipes), Serra, ES, Brazil;9. Universidade Federal do Espírito Santo (UFES), Programa de Pós-Graduação em Saúde Coletiva, Departamento de Educação Integrada à Saúde, Vitória, ES, Brazil;10. Universidade Federal do Espírito Santo, Programa de Pós-Graduação em Saúde Coletiva, Departamento de Estatística, Vitória, ES, Brazil
Abstract:ObjectiveTo characterize the influence of birthplace on outcomes of patients with gastroschisis admitted to three hospitals in a state in Brazil’s southeastern region, according to condition inborn (born in a reference center) or outborn (born outside the reference center).MethodsRetrospective multicenter cohort study of patients with gastroschisis. The sample size utilized was of patients admitted in three hospitals with a diagnosis of gastroschisis ICD 10 Q79.3 between January 2000 to December 2018. Patients were divided into two groups, inborn and outborn. Characteristics of prenatal, perinatal and postoperative were compared using statistical tests. The level of significance adopted was P-value < 0.05.ResultsIn total, 144 cases of gastroschisis were investigated. The outborn patients group had higher rates of absence of antenatal diagnosis (p = 0.001), vaginal delivery (p = 0.001), longer time between birth and abdominal wall closure surgery (p = 0.001), to silo removal (p = 0.001), to first enteral feeding (p = 0.008), for weaning from mechanical ventilation (p = 0.034), used less peripherally inserted central catheter (PICC) and required more venous dissections (p = 0.001), and lower mean of serum sodium (p = 0.015). There were no differences in mortality rates and length of hospital stay between the inborn and outborn groups.ConclusionAlthough outborn patients with gastroschisis were less likely to have an antenatal diagnosis and were more prone to a longer time to undergo surgical and feeding procedures, and to spend more time in mechanical ventilation, these disadvantages seemed not to reflect on the death rate and the length of hospital stay of patients from this group.
Keywords:Gastroschisis  Birth defects  Prenatal diagnosis  Neonatal surgery  Neonatal intensive care unit
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