Clinical characteristics,rates of blindness,and geographic features of PACD in China |
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| Affiliation: | 2. Beijing Ophthalmology and Visual Science Key Lab;3. Beijing Institute of Ophthalmology;4. Beijing Clinical Service Center;5. The First Affiliated Hospital of Harbin Medical University, Harbin, China;11. Xi’an Fourth Hospital;12. Tang Shan City Eye Hospital;8. The First Hospital of Shijiazhuang City, Shijiazhuang, China;9. Tianjin Eye Hospital, Tianjin, China;112. Lanzhou University Second Hospital, Lanzhou, China;123. Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China;84. No. 1 Hospital of Xi ’An City, Xi''an, China;95. The Second Hospital of Heibei Medical University, Shijiazhuang, China;1111. The Eye Hospital of Wenzhou Medical University, Wenzhou, China;1212. The 4th Affiliated Hospital of China Medical University, the Eye Hospital of China Medical University, Shenyang, China;88. Xuanwu Hospital, Capital Medical University;99. The First People’s Hospital of Xuzhou, Xuzhou, China;11112. The Affiliated Hospital of Southwest Medical University, Chongqing, China;12123. The Third Medical Center of Chinese PLA General Hospital;884. The Second Hospital of Jilin University, Changchun, China;995. Zibo Central Hospital, Zibo, China;111111. ShiYan People’s Hospital, Shiyan, China;121212. Yichang Central Hospital, Yichang, China;888. The First People’s Hospital of Foshan, Foshan, China;999. Liuzhou People’s Hospital, Liuzhou, China;1111112. Taihe Hospital, Hubei University of Medicine, Shiyan, China;1212123. Huashan Hospital of Fudan University, Shanghai, China;8884. The First Affiliated Hospital of Dalian Medical University, Dalian, China;9995. Hebei Eye Hospital, Xingtai, China;11111111. Wuxi NO.2 People''s Hospital, Wuxi, China;12121212. Taian Central Hospital, Taian City, China;8888. The Third Medical Center of Chinese PLA General Hospital, Beijing, China;9999. Palo Alto Medical Foundation, San Francisco, the United States |
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| Abstract: | ObjectiveTo analyze the rates of blindness with the demographics and clinical characteristics of patients with primary angle-closure disease (PACD) to provide a comprehensive epidemiologic reference in China.MethodsA retrospective analysis was conducted in the Chinese Glaucoma Study Consortium database, which is a national multicenter glaucoma research alliance of 111 hospitals participating between December 21, 2015 and September 9, 2018. The diagnosis of PACD was made by qualified physicians through examination. Comparison of sex, age, family history, subtypes of PACD, and blindness were analyzed.ResultsA total of 5762 glaucoma patients were included, of which 4588 (79.6%) had PACD. Of PACD patients, 72.1% were female with the sex ratio (F/M) of 2.6, and the average age of patients was 63.8±9.3 years with the majority between 60 and 70 years. Additionally, 30% of these patients had low vision in one eye, 8.8% had low vision in both eyes, 1.7% had blindness in one eye, and 0.3% had blindness in both eyes. There were statistical differences with regards to age between male and female patients with PACD, with male patients being older on average. Primary angle-closure glaucoma was more commonly diagnosed in males (60%) compared to females (35.9%), whereas acute primary angle closure (APAC) was more commonly diagnosed in females (54.3%) compared to males (37.7%). The visual acuity in APAC patients was lower and the rate of low vision and blindness was higher than other subtypes.ConclusionPACD was the major type of glaucoma in Chinese hospitals. There were more female patients with PACD, mostly between 60 and 70 years old, with higher rates of APAC in women. APAC resulted in the worst visual outcomes of all PACD subtypes. |
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