Unmasking Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome due to Granulocyte Colony-Stimulating Factor Use in a Patient with a Poorly Differentiated Germ Cell Neoplasm |
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| Authors: | Nathan C. Bahr James Wallace Anne E.P. Frosch David R. Boulware |
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| Affiliation: | aDepartment of MedicineCenter for Infectious Diseases and Microbiology Translational Research, Minn., USA;bCenter for Infectious Diseases and Microbiology Translational Research, Minn., USA;cDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minn., USA |
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| Abstract: | Cryptococcal meningitis immune reconstitution inflammatory syndrome (IRIS) is frequently seen in patients with HIV and less frequently in patients on immune suppressive medications for other conditions. Here, we describe the first reported case of unmasking cryptococcal IRIS due to granulocyte colony-stimulating factor used in an HIV-negative patient with chemotherapy-induced neutropenia.Key words: Cryptococcal meningitis, Immune reconstitution inflammatory syndrome, Granulocyte colony-stimulating factor, Immunosuppressed host, Chemotherapy |
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