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| 重度抑郁症症状缓解前后海马局部一致性研究 | |
| 引用本文： | 王丽,姚志剑,卢青,刘海燕,陈景旭,卞清涛. 重度抑郁症症状缓解前后海马局部一致性研究[J]. 中国神经精神疾病杂志, 2010, 36(5) |
| 作者姓名： | 王丽 姚志剑 卢青 刘海燕 陈景旭 卞清涛 |
| 作者单位： | 1. 北京回龙观医院,北京,100096 2. 南京医科大学脑科医院 3. 东南大学学习科学研究中心 |
| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划)，儿童发展与学习科学教育部重点实验室开发课题 |
| 摘 要： | 目的观察静息态下发作期重度抑郁症患者的海马功能,以及其在抗抑郁药物治疗达临床痊愈后的变化。方法对20例24项汉密尔顿抑郁量表(HAMD24)总分35分的重度抑郁症患者在治疗前、治疗8周达临床痊愈(HAMD24减分率≥75%)后进行静息态fMRI扫描,以性别、年龄、受教育程度匹配的20名正常人做对照组。采用局部一致性(regional homogeneity,ReHo)作为海马功能的测量指标。结果治疗前患者组较正常对照组左海马ReHo值增高,差异具有统计学意义(P0.05);但患者组治疗前与治疗后、治疗后与正常对照组的左海马ReHo值的差异均无统计学意义(P0.05)。患者组治疗前、治疗后、正常对照组中每两组间右海马ReHo值的差异均无统计学意义(P0.05)。结论重度抑郁症患者海马功能受损,存在侧化现象,经短期系统的抗抑郁药物治疗达临床痊愈后,这种损伤未见有效逆转。 |
| 关 键 词： | 抑郁症 磁共振成像 静息态 抗抑郁药物 海马 |
Regional homogeneity of hippocampus of major depressed patients before and after clinical recovery |
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| WANG Li,YAO Zhijian,LU Qing,LIU Haiyan,CHEN Jingxu,BIAN Qingtao. Regional homogeneity of hippocampus of major depressed patients before and after clinical recovery[J]. Chinese Journal of Nervous and Mental Diseases, 2010, 36(5) | |
| Authors: | WANG Li YAO Zhijian LU Qing LIU Haiyan CHEN Jingxu BIAN Qingtao |
| Affiliation: | WANG Li,YAO Zhijian,LU Qing,LIU Haiyan,CHEN Jingxu,BIAN Qingtao.Nanjing Brain Hospital,Nanjing Medical University,Nanjing.210029.China |
| Abstract: | Objective The present study were to use fMRI to investigate the characteristics of the hippocampal activities of heavy depressed patients during the major depressive episode and remission after antidepressant treatment.Methods Twenty patients with major depressive disorder who had a minimum score of 35 on the 24-item Hamilton Depression Rating Scale(HAMD24)received resting-state fMRI scans before and after eight-week treatment.After eight-week treatment,the patients who had reached remission(reduced rate of... |
| Keywords: | Major depressive disorder Magnetic resonance imaging Resting state Antidepressant treatment Hippocampus |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |