Lymphocyte subsets in pediatric migraine |
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Authors: | Aron Cseh Kristof Mark Farkas Laszlo Derzbach Katalin Muller Barna Vasarhelyi Balazs Szalay Andras Treszl Viktor Farkas |
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Institution: | 1. Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, Bókay u. 53-54, Budapest, 1083, Hungary 2. First Department of Pediatrics, Semmelweis University, Budapest, Hungary 3. Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary
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Abstract: | Aseptic inflammation due to activated immune cells has been implicated in the pathomechanism of migraine. We measured the prevalence of regulatory T cells (Tregs), along with that of CD4+/CD8+ lymphocytes and their Th1/Th2 commitment in pediatric migraine. Children and adolescents suffering from migraine without aura, migraine with aura and hemiplegic migraine ictally (n = 53, 27, and 20, respectively), also interictally (n = 33) were recruited and compared to 24 healthy children. Our results indicated comparable prevalence of Tregs, CD4+ and Th1/Th2 committed cells. CD8+ prevalence was lower, and CD4+/CD8+ ratio was higher in ictal phase irrespective of the subtype of migraine. No association between CD8+ prevalence and gender, body weight, disease onset and attack duration in migraine subtypes was found. CD8+ prevalence was normal in patients in interictal phase. These results suggest the absence of major systemic alteration of adaptive immunity in children and adolescents suffering from migraine; however, a transient decrease of CD8+ prevalence during the ictal phase was detected irrespective of the subtype of migraine. |
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