| 西洋参茎叶皂苷对大鼠心肌细胞Ca2+内流的影响 |
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| 引用本文： | 关利新,衣欣,杨世杰,吕怡芳.西洋参茎叶皂苷对大鼠心肌细胞Ca2+内流的影响[J].中药药理与临床,2004,20(6):8-9. |
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| 作者姓名： | 关利新 衣欣 杨世杰 吕怡芳 |
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| 作者单位： | 1. 牡丹江医学院药理教研室,牡丹江,157011
2. 吉林大学基础医学院药理教研室,长春,130021 |
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| 摘 要： | 目的:研究西洋参茎叶皂苷(PQS)对大鼠心肌细胞Ca2 内流的影响.方法:应用钙离子荧光指示剂Fura-2/AM检测.结果:PQS(1.5mg/ml)和维拉帕米(0.5μmol/L)对静息状态下心肌细胞内Ca2 浓度均无明显影响,但PQS使心肌细胞内Ca2 浓度有下降趋势;两药可明显抑制高钾(50mmol/L)引起的心肌细胞内Ca2 浓度的升高.结论:PQS对心肌细胞电压依赖性钙通道有阻断作用.
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| 关 键 词： | 西洋参茎叶皂苷 心肌细胞 钙通道 钙离子 |
The effect of saponins extracted from stem and leaves of Panax quinquefolium on Ca2+ entry at rat myocardial cells |
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| Guan Lixin,Yi Xin,Yang Shijie ,LiuYifang.The effect of saponins extracted from stem and leaves of Panax quinquefolium on Ca2+ entry at rat myocardial cells[J].Pharmacology and Clinics of Chinese Materia Medica,2004,20(6):8-9. |
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| Authors: | Guan Lixin Yi Xin Yang Shijie LiuYifang |
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| Institution: | Guan Lixin,Yi Xin,Yang Shijie 1,LiuYifang 1 |
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| Abstract: | Objecteve: To investigate the effect of saponins extracted from stem and leaves of Panax quinquefolium(PQS) on Ca 2 entry. Methods: Fura 2/AM at freshly isolated rat ventricular myocytes. Results: PQS(1.5mg/ml) had no significant effect on resting myocardial cells Ca 2 ]i, but had the tendency to make the resting myocardial cells Ca 2 ]i decline; PQS(1.5mg/ml) could depress the increase of ventricular myocytes Ca 2 ]i induced by KCl (50mmol/L). Conclusion: PQS has an inhibitory effect on the Ca 2 entry through blockade of voltage dependent calcium channel. |
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| Keywords: | saponins extracted from stem and leaves of Panax quinquefolium myocardial cells Ca~(2 ) channel |
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