现场应用青蒿琥酯预防日本血吸虫感染的效果分析

目的　观察现场应用青蒿琥酯预防日本血吸虫感染的效果。方法　将5098名接触疫水者随机分为青蒿琥酯组和安慰剂组，剂量均为6mg/kg顿服，在接触疫水后7～10d开始服药，每2wk服1次，脱离疫水后1wk内再服1次，末次服药后4wk，用尼龙袋集卵孵化法加改良加藤法进行效果考核。结果　青蒿琥酯组粪检阳性9例，阳性率0.37%（9/2438），无急性血吸虫病发生；而对照组粪检阳性189例，阳性率7.11%（189/2660），有5例发生急性血吸虫病。结论　口服青蒿琥酯能有效预防日本血吸虫感染。

THE EFFECT ANALYSIS OF USING ARTESUNATE TO PREVENT SCHISTOSOME INFECTION IN THE FIELD

Objective To observe the effect of artesunate to prevent schistosomiasis in the field. Methods 5 098 residents who contacted with infective water were randomly divided into two groups, group Ⅰ received artesunate 6 mg/kg once every 2 weeks when 7-10 day after contacting with infective water and took one more dosage after ceasing contacting the infective water for one week, group Ⅱ received the same dosage of placebo at the corresponding times. Four weeks after the last administration, hatching method and Katos method were used for stool examination to evaluate the effect. Results 9 cases were stool positive in group Ⅰ with an infection rate of 0.37%(9/2438), no acute schistosomiasis, while 189 cases were stool positive in group Ⅱ with an infection rate of 7.11%(189/2660). Conclusion Artesunate could protect the residents from Schistosome japonicum infection.