Development and organization of the human brain tissue compartments across the lifespan using diffusion tensor imaging |
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Authors: | Hasan Khader M Sankar Ambika Halphen Christopher Kramer Larry A Brandt Michael E Juranek Jenifer Cirino Paul T Fletcher Jack M Papanicolaou Andrew C Ewing-Cobbs Linda |
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Affiliation: | Department of Diagnostic and Interventional Imaging, University of Texas-Houston Health Science Center, Houston, Texas, USA. Khader.M.Hasan@uth.tmc.edu |
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Abstract: | We used a diffusion tensor imaging-based whole-brain tissue segmentation to characterize age-related changes in (a) whole-brain grey matter, white matter, and cerebrospinal fluid relative to intracranial volume and (b) the corresponding brain tissue microstructure using measures of diffusion tensor anisotropy and mean diffusivity. The sample, a healthy cohort of 119 right-handed males and females aged 7-68 years. Our results demonstrate that white matter and grey matter volumes and their corresponding diffusion tensor anisotropy and mean diffusivity follow nonlinear trajectories with advancing age. In contrast, cerebrospinal fluid volume increases linearly with age. |
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