| 胎脾LAK细胞联合rlL－2治疗癌性胸水临床观察 |
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| 引用本文： | 朱铁年,赵瑞景,周学敏,刘文虎,孔月,孙志学. 胎脾LAK细胞联合rlL－2治疗癌性胸水临床观察[J]. 中国肿瘤临床, 1995, 0(5) |
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| 作者姓名： | 朱铁年 赵瑞景 周学敏 刘文虎 孔月 孙志学 |
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| 作者单位： | 河北省肿瘤医院，河北医学院免疫学教研室 |
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| 摘 要： | 以人胎脾淋巴细胞体外在ｒＩＬ－２存在下诱导成ＬＡＫ细胞并与ｒｌＬ－２联合胸内注入，治疗７例癌性胸水患者。其中１例胸水完全消失，其余患者胸水明显减少，出现胸膜肥厚，连续观察８个月胸水未见进一步增多；胸水内肿瘤细胞也明显减少。７例患者均未出现任何不良反应。结果提示：胎脾ＬＡＫ细胞与ｒＩＬ－２胸腔内联合应用治疗癌性胸水有效，可延长患者生存期。
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| 关 键 词： | LAK细胞，基因重组白细胞介素2，恶性胸水，免疫疗法 |
Intrapleural Transfer of Recombinant Interleukin-2 with Allogeneic LAK Cells from Human Fetal Spleens in the Treatment of Malignant Pleural Effusion |
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| Zhu Tie-Nian,Zhao Rui-Jing,Zhou Xue-Min et al. Intrapleural Transfer of Recombinant Interleukin-2 with Allogeneic LAK Cells from Human Fetal Spleens in the Treatment of Malignant Pleural Effusion[J]. Chinese Journal of Clinical Oncology, 1995, 0(5) |
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| Authors: | Zhu Tie-Nian Zhao Rui-Jing Zhou Xue-Min et al |
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| Abstract: | Seven Patients with malignant Pleural effusion were treated with intrapleural transfer of allogeneic LAK cells which were induced from lymphocytes of human fetal spleens in the presence of rIL-2 and rIL-2 combination.The results showed that the pleural effusion disappeared in one patient and significantly reduced without any increases during eight months follow-up after treatment in the others. The number of tumor cells in the pleural effusion was remarkably decreased. No serious side effects were observed in any of the patients. The results indicated that transfer of fetal LAK cells combined with rIL-2 in the treatment of patients with malignant pleural effusion was effective. The survival of these patients was prolonged. |
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| Keywords: | Malignant pleural effusion LAK cells rIL-2 Immunotherapy |
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