耳聋相关分子生物学研究

耳聋病因复杂,由多种因素共同引起,其中约60％的耳聋患者具有遗传背景,根据遗传方式遗传性耳聋分为常染色体隐性遗传、常染色体显性遗传、伴性遗传和线粒体基因遗传。随着分子生物学和遗传学的飞速发展,极有力地促进了耳聋基因的定位和克隆,有利于我们更深入了解耳聋的发病机制。本文综述了近年来国内分子生物学领域内耳聋发病机制研究进展,并对其研究前景作了展望。

Progress of molecular genetics research on deafness in China

Deafness is etiologically influenced by many factors. Approximately 60% of patients with deafness have genetic defects, Their inheritances may be autosomal dominant, autosomal recessive, X-linked, or mitochondrial. The advances in genetics and molecular biology have been rapidly promoting the identification and cloning of the genes related to deafness, which help us to understand the pathogenesis of deafness greatly, This article reviews the molecular biological advances on pathogenesis of deafness, especially focus on research progress in China, The prospective development of the field is discussed,