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Degeneration of cortical function in the Royal College of Surgeons rat |
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| Authors: | Gias Carlos Vugler Anthony Lawrence Jean Carr Amanda Jayne Chen Li Li Ahmado Ahmed Semo Ma'ayan Coffey Peter J |
| Institution: | Institute of Ophthalmology, University College London, 11-43 Bath Street, EC1V 9EL London, UK |
| Abstract: | The purpose of the current study was to determine the progress of cortical functional degeneration in the Royal College of Surgeons (RCS) rat. Cortical responses were measured with optical imaging of intrinsic signals using gratings of various spatial frequencies. Subsequently, electrophysiological recordings were also taken across cortical layers in response to a pulse of broad-spectrum light. We found significant degeneration in the cortical processing of visual information as early as 4 weeks of age. These results show that degeneration in the cortical response of the RCS rat starts before development has been properly completed. |
| Keywords: | c/d cycles per degree of visual field c/s cycles per second spk/s spikes per second COA centre of activity ERG electroretinogram LFP local field potentials MUA multi-unit activity RCS Royal College of Surgeons RPE retinal pigment epithelium SD standard deviation |
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