| RyR2磷酸化在心力衰竭中的作用 |
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| 引用本文： | 陈会花.RyR2磷酸化在心力衰竭中的作用[J].复旦学报(医学版),2017,44(3):359-362. |
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| 作者姓名： | 陈会花 |
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| 作者单位： | 上海中医药大学病理教研室 上海 201203 |
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| 基金项目： | 国家自然科学基金(81373858) |
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| 摘 要： | 心力衰竭在细胞水平主要表现为心肌以兴奋 收缩耦联(excitement contraction coupling,ECC)为基础的收缩功能障碍,而Ca2+信号转导在此过程中起着非常重要的作用。肌浆网(sarcoplasmic reticulum,SR)兰尼碱受体(ryanodine receptor type 2,RyR2)是心肌最重要的钙释放通道,RyR2磷酸化是肌浆网钙释放的基础,而RyR2磷酸化主要受蛋白激酶A (protein kinase A ,PKA)和钙离子/钙调蛋白依赖性蛋白激酶Ⅱ (calcium/calmodulin dependent protein kinase Ⅱ,CaMKⅡ)的调控。目前对RyR2磷酸化的研究已经非常广泛,但对其涉及心力衰竭的具体发病机制仍有争议,本综述主要针此问题进行阐述。
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| 关 键 词： | 兰尼碱受体 心力衰竭 蛋白激酶A 钙离子/钙调蛋白依赖性蛋白激酶Ⅱ |
The role of RyR2 phosphorylation in heart failure |
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| CHEN Hui-hua,ZHANG Chen,LYU Rong.The role of RyR2 phosphorylation in heart failure[J].Fudan University Journal of Medical Sciences,2017,44(3):359-362. |
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| Authors: | CHEN Hui-hua ZHANG Chen LYU Rong |
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| Institution: | Department of Pathology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China |
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| Abstract: | Heart failure is mainly characterized by myocardial systolic dysfunction ,which is based on excitement contraction coupling on the cellular level,and calcium (Ca2+)signaling plays a very important role in this process.The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major Ca2+ source of required for cardiac muscle excitation contraction coupling.RyR2 phosphorylation is the basis of SR calcium release,and RyR2 phosphorylation is mainly controled by protein kinase A (PKA) and calcium/calmodulin dependent protein kinase Ⅱ (CaMK Ⅱ).Although widely research in this area,excessive activation of RyR2 phosphorylation involved in the pathogenesis of heart failure are still controversial,which is discussed in this review. |
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| Keywords: | ryanodine receptor heart failure protein kinase A calcium/calmodulin dependent protein kinase Ⅱ |
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